STEAM (Science, Technology, Engineering, Arts, Mathematics) learning is designed to contextualize the abstract concepts of science in chemistry learning. Integration STEAM in chemistry learning needs a learning model to help students understand real-world problems. For this reason, STEAM-PBL (Project Based Learning) was employed. This paper reports on the implementation of STEAM-PBL using project Daphnia Sp. The features of this study can be summarized as follows. First, in combination with students' experience, the content of this study derived from a real-life problem to understand chemistry concepts using the project. Second, the objective of this study attaches specific responses to students' interests in learning chemistry. Third, implementing digital platforms such as Instagram promotes chemistry learning and enhances students' digital literacy skills. In all, this study provides a reference for integrating STEM-PBL courses. It may contribute to the acceleration of training professionals and the construction of innovation-oriented learning in chemistry.