Purpose: Combining an online and traditional mode of learning is a significant challenge for third world countries. To face this challenge, educational institutions around the world adopted the strategies of blended learning (BL). This research aims to determine the factors affecting readiness to diffuse BL in Pakistani higher education institutions. Design/methodology/approach: "Partial least squares structural equation modeling (PLS-SEM)" was used based on a suitable sample of 228 participants in Karachi, Pakistan. Findings: The results reveal that resource support, management strategies (MSs) and technology infrastructure (TI) are positively and significantly associated with readiness to diffuse BL. However, institutional structure (IS) and ethical consideration (EC) have a positive but insignificant link with readiness to diffuse BL. Originality/value: The research is reasonably required as research in the Karachi Pakistani context is scarce. Additionally, this study analyses the possibility of modern skills and techniques to diffuse BL in higher education in Pakistan.