We discuss transforming STEM education using three aspects: learning progressions (LPs), constructed response performance assessments, and artificial intelligence (AI). Using LPs to inform instruction, curriculum, and assessment design helps foster students' ability to apply content and practices to explain phenomena, which reflects deeper science understanding. To measure the progress along these LPs, performance assessments combining elements of disciplinary ideas, crosscutting concepts and practices are needed. However, these tasks are time-consuming and expensive to score and provide feedback for. Artificial intelligence (AI) allows to validate the LPs and evaluate performance assessments for many students quickly and efficiently. The evaluation provides a report describing student progress along LP and the supports needed to attain a higher LP level. We suggest using unsupervised, semi-supervised ML and generative AI (GAI) at early LP validation stages to identify relevant proficiency patterns and start building an LP. We further suggest employing supervised ML and GAI for developing targeted LP-aligned performance assessment for more accurate performance diagnosis at advanced LP validation stages. Finally, we discuss employing AI for designing automatic feedback systems for providing personalized feedback to students and helping teachers implement LP-based learning. We discuss the challenges of realizing these tasks and propose future research avenues.