Compares differences in function and behavior of two oxygen-binding proteins, myoglobin found in muscle and hemoglobin found in blood. Describes the mechanism of oxygen-binding and allosteric effect in hemoglobin; also describes the effect of pH on the affinity of hemoglobin for oxygen. (CS)

A one-hour presentation given to veterinary medical students at Texas A&M University during their first week of professional school is summarized. It helps the students place some of their subjects and disciplines in perspective, emphasizing the overall morphologic organizational scheme of the higher vertebrate body. (LBH)

Describes the nature and action of hematopoietic proteins which regulate the production of specific sets of blood cells. Discusses the production of these hematopoietins by recombinant-DNA methods in an effort to enable physicians to treat patients by eliciting production of specific types of blood cells. (CW)

Discusses the role of zinc in various enzymes concerned with hydration, hydrolysis, and redox reactions. The binding of zinc to protein residues, properties of noncatalytic zinc(II) and catalytic zinc, and the reactions catalyzed by zinc are among the topics considered. (JN)

The catechol dioxygenases are bacterial iron-containing enzymes that catalyze the oxidative cleavage of catechols. These enzymes serve as a component of nature's mechanisms for degrading aromatic compounds in the environment. The structure and mechanistic aspects of these enzymes are described. (JN)

Discusses how a metal ion is bound to a particular enzyme, focusing the blue copper centers found in a variety of organisms. Coordination geometry of the blue copper site, donor set, direct structural studies, and single-crystal spectroscopy are the major topic headings. (JN)

Offers four reasons for making biochemistry as an option for satisfying the general education science requirement: (1) scientific skills--objectivity, reasoning, and method; (2) broader perspective; (3) integration of beginning and advanced topics; and (4) relevance. (JM)

Presents the synthesis of the science of enzymology from application of the concepts of physical organic chemistry from a historical perspective. Summarizes enzyme and coenzyme mechanisms elucidated prior to 1963. (JM)

Scientific ideas of the biological laboratory are turned into economic realities in industry only after several problems are solved. Economics of scale, agitation, heat transfer, sterilization of medium and air, product recovery, waste disposal, and future developments are discussed using aerobic respiration as the example in the scale-up…

A three-period experiment was developed to help students visualize asymmetric distribution of proteins within membranes. It includes: (1) isolating erythrocyte membranes; (2) differential labeling of intact erythrocytes and isolated erythrocyte membranes with an impermeable fluorescent dye; and (3) separating proteins by polyacrylamide gel…

The immune system includes the most diverse proteins known because they are encoded by hundreds of scattered gene fragments which can be combined in millions or billions of ways. Events of immune response, binding of antigens, antibody structure, T-cell receptors, and other immunologically-oriented topics are discussed. (DH)

Only a few substances serve as signals within cells; this indicates that internal signal pathways are remarkably universal. The variety of physiological and biochemical processes regulated by known messengers is discussed along with chemical structures, pathways, inositol-lipid cycles, and cell growth regulation. (DH)

Uses the subject of enzymes to illustrate the topical approach to teaching biochemistry at the secondary level. Includes the procedures for three experiments dealing with various aspects of enzymes. (JN)

Discusses a simulation on enzyme kinetics based upon the ability of computers to generate random numbers. The program includes: (1) enzyme catalysis in a restricted two-dimensional grid; (2) visual representation of catalysis; and (3) storage and manipulation of data. Suggested applications and conclusions are also discussed. (DH)

Describes quick and easy experiments that yield quantitative information on a variety of levels, emphasize the concept of experimental controls, and integrate the experimental with the theoretical using the organic phosphates as the experimental system. Background information, list of materials needed, and procedures used are included. (JN)