While it is now argued that intellectual giftedness is not causally associated with well-being, the individual and environmental determinants associated remain empirically underexplored. Trying to fill this gap, this study investigated potential risk and protective factors on the well-being and mental health of 219 Canadian intellectually gifted adults. Exploratory transversal analyses were conducted between 11 determinants frequently evoked in the literature on intellectually gifted individuals and hedonic well-being (positive/negative affect; [direct proportionality] = 0.85-0.87; satisfaction with life; [direct proportionality] = 0.88), eudemonic well-being (existential crisis/meaning in life; [direct proportionality] = 0.76-0.87; interpersonal connection; [direct proportionality] = 92) and psychopathologies. Results show that twice-exceptionality and lower socioeconomic status are risk factors for the development of psychopathologies, while being married/in civil union and having a higher perceived level of potential achievement are protective factors for hedonic and eudemonic well-being. Results are discussed in light of previous knowledge about gifted individuals.