Introduction: Children with Down Syndrome are more likely to experience sleep issues throughout their life compared to typically developing children. Sleep difficulties also affect caregivers, who are at increased risk of sleep disturbances, mood disturbances and poorer wellbeing. However, the impact of poor sleep in this cohort of children on their caregivers is not widely understood. Method: This study assessed the quality of life and mental health in 26 caregivers of children with Down Syndrome and sleep problems through two self-reporting questionnaires. Results: Results showed caregivers had significantly lower quality of life (QoL) and higher stress scores compared to population norms. A decrease in psychological and physical health scores was associated with higher odds of depression. Similarly, a reduced physical and social health increased the odds of experiencing stress by 50%. Conclusion: These findings suggest this cohort of families may benefit from increased psychosocial support when addressing sleep problems.