Impairment of hippocampal function precedes frontal and parietal cortex impairment in human Alzheimer's disease(AD). Neurotrophins are critical for behavioral performance and neuronal survival in AD. We used complex and radial mazes to assess spatial orientation and learning in wild-type and B6-Tg(ThylAPP)23Sdz (APP23) animals, a transgenic mouse…

Classical fear conditioning requires the recognition of conditioned stimuli (CS) and the association of the CS with an aversive stimulus. We used Affymetrix oligonucleotide microarrays to characterize changes in gene expression compared to naive mice in both the amygdala and the hippocampus 30 min after classical fear conditioning and 30 min after…

Damage to the medial region of the thalamus, both in clinical cases (e.g., patients with infarcts or the Korsakoff's syndrome) and animal lesion models, is associated with variable amnesic deficits. Some studies suggest that many of these memory deficits rely on the presence of lateral thalamic lesions (LT) that include the intralaminar nuclei,…

This manual was developed by the Community Resource Curriculum Development Project (CRCDP), a cooperative project to develop multi-disciplinary, multi-ethnic, multi-cultural science/social sciences teaching units based upon the Illinois State Goals for Learning and the Chicago Public Schools outcomes for a seamless kindergarten, first, and second…

This is an activity book designed for students in grades 3 through 6. These activities incorporate science themes and cooperative learning. Students explore topics by working with others as team members to complete the science activities. This book contains five units on the following topics: weather, insects, plants, dinosaurs, and space. Each…

This book presents 15 tales that bring the animal world into the classroom. The stories in this book are divided into two sections: stories from aquatic ecosystems (both fresh- and saltwater systems), and from terrestrial systems, including desert, meadow, woodland, mountain, Arctic tundra, savanna, pine forest, and jungle ecosystems. All predator…

This book is part of a series of books presenting ready-to-use instructional units on themes typically taught in the primary grades. The topics focus on science, math, social studies or literature, but use language arts skills consistently in each unit. Each book in the series also uses as many frames of mind or intelligences as possible. Within a…

This record book is intended for use by agricultural education students who have ownership arrangements in animal enterprise experience programs. A major purpose of this book is to aid in separating out or allocating the costs and returns to a specific enterprise. The financial, labor, and management aspects of each enterprise can then be studied…

Noting the importance of whole concept learning as opposed to fragmented non-meaningful facts, this paper presents a unit of study on animal habitats that is geared for a first-grade whole-language classroom in the later stages of the year. The major objective of the unit presented in the paper is for students to be able to identify the habitats…

One of a series of documents produced by a nationwide network of early childhood education specialists, teachers, parents, and Head Start staff, this nature trail guide for exploring the outdoors is intended as a supplemental teaching aid for teachers or parents. The guide identifies and illustrates the most predominant and readily observable…

"Man and the Gulf of Mexico (MGM)" is a marine science curriculum developed to meet the marine science needs of tenth through twelfth grade students in Mississippi and Alabama schools. This MGM unit, which focuses on marine and estuarine ecology, is divided into six sections. The first section contains unit objectives, discussions of the…

Activities in this teacher's packet are designed to familiarize secondary school students with the responsibilities involved in pet ownership. Teaching plans are provided for a total of 12 lessons grouped under social studies, language arts, math, and health sciences. Activities focus on pet overpopulation, expressions of social responses in…

Designed to sensitize preschoolers and kindergartners to the responsibilities involved in caring for living things, this teacher's packet provides a variety of student worksheets and activity suggestions. Teaching plans are provided for a total of nine lessons, which can be easily integrated into other learning areas such as numbers, colors,…

Describes sources and housing of laboratory rats for use in investigating behavior. (LS)