This study modelled the Mediating Role of Work-Life Balance on the Relationship between Work Arrangement and Employee Performance in Higher Education. The explanatory research design was adopted for this study, and a sample of 316 was drawn from a study population of 2,045 administrative staff of a public university in Ghana. A questionnaire was used for the data collection, and data gathered were analyzed with Partial Least Square-Structural Equation Modelling. The study found that flexible work arrangements and wellness programs are individually and significantly related to employee performance and work-life balance. Also, family responsibilities significantly influenced employee performance but had a non-significant relationship with work-life balance. It can also be concluded that work-life balance significantly mediated the relationship between flexible work arrangements and employee performance as well as wellness programs and employee performance. It is recommended that human resource managers in academia should take specific action to enhance work-life balance among their administrative staff to elicit higher performance from them.