Controlling Type 1 error and encouraging reproducible research are important in clinical and translational research. These concepts are frequently discussed in lectures with mathematical language, analytic examples, and probability distributions that demonstrate the issues. However, first-time learners in biostatistics courses focusing on fundamental topics may benefit from a more interactive demonstration in which learners participate, contribute to the results, and have a personal stake in the outcomes. This article summarizes a simple activity using dice to simulate Type 1 error that requires minimal preparation and cost. The activity may be appropriate for learners enrolled in a first course in statistics, biostatistics, or probability.