The biotechnology revolution is making contributions to the improvement of health care. Some of the biotechnology-based pharmaceuticals in the marketplace include human hormones, enzymes, enzyme inhibitors, vaccines, immunomodulators, growth factors, and monoclonal antibodies. Many new diagnostics will appear and be used by patients in their own…

Presents a protocol that can be used to discover that S. marcescens produces a bright red pigment when exposed to one temperature condition and does not produce this color under other conditions. Enables students to connect gene expression and environmental changes. (DDR)

Since the identification of the FMR1 gene basic research has been focused on the molecular characterization of the FMR1 gene product, the fragile X mental retardation protein (FMRP). Recent developments in fragile X research have provided new insights and knowledge about the physiological function of FMRP in the cell and the nerve cell in…

Fragile X syndrome is the most common heritable form of mental retardation caused by loss-of-function mutations in the "FMR1" gene. The "FMR1" gene encodes an RNA-binding protein that associates with translating ribosomes and acts as a negative translational regulator. Recent work in "Drosophila melanogaster" has shown that the fly homolog of…

In the present study we confirm the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients. We further examine the involvement of the mitochondrial aspartate/glutamate carrier gene ("SLC25A12") in…

Proposes models for the evolution of the genetic code and translation mechanisms. Suggests that the translation process is so complex and precise that it must have evolved in many stages, and that the evolution of the code was influenced by the constraints imposed by the evolving translation mechanism. (EB)

Addresses issues related to genetic counseling and deafness. (Author/VWL)

Discusses genetics and its relevance to the lives of deaf people. Examines how the advances in genetics technologies have led to greater knowledge regarding the genetic causes of deafness and how this impacts the deaf community. (Author/VWL)

This article undertakes a close rhetorical reading of the speeches given by Bill Clinton, Tony Blair, Francis Collins, and Craig Venter on June 26, 2000, at the White House ceremony announcing the completion of the Human Genome Project. Specifically, it looks at the metaphors used by each speaker to describe the activity of genomic scientists.…

In 1889, German biologist August Weissmann showed that mice whose tails are cut off do not produce short-tailed offspring. It was a step forward for science, but a step backward for civilization. Weissmann's discovery was good for science because, contrary to what many scientists had believed, acquired characteristics are not, of course,…

The ethics of the use of genetic screening and reproductive technologies to select against and for deafness is presented. It is argued that insofar as deafness is a disability it is ethical to act in such a way as to avoid the conception or birth of children with genetic or congenital deafness. The discovery and recognition of signing deaf…

In response to the alarming growth in autism diagnoses, Congress passed the Combating Autism Act of 2006 (P.L. 109-416), which established the Interagency Autism Coordinating Committee (IACC) to coordinate all efforts within the U.S. Department of Health and Human Services related to ASD. The Combating Autism Act requires that, in addition to…

Evolutionary-biological reasoning suggests that individuals should be differentially susceptible to environmental influences, with some people being not just more vulnerable than others to the negative effects of adversity, as the prevailing diathesis-stress view of psychopathology (and of many environmental influences) maintains, but also…

Plants defend themselves against pathogens via the expressions of disease resistance (R) genes. Many plant R gene products contain the characteristic nucleotide-binding site (NBS) and leucine-rich repeat (LRR) domains. There are highly conserved motifs within the NBS domain which could be targeted for polymerase chain reaction (PCR) cloning of R…