This Case Study is based on original research applying a single-case multiple baseline across participants design to investigate the effects of naturalistic augmentative and alternative communication instruction during routines for social closeness for three young neurodiverse children. This Case Study focuses on why a single-case design (SCD) was chosen, what individualizations were made to the intervention for each participant, and lessons learned while using a SCD. Readers will learn the advantages of SCD, when and how it can be applied, and some practical tips for applying these types of methods. [This content is provided in the format of an e-book.]