Developing treatment strategies to enhance memory is an important goal of neuroscience research. Activation of multiple biochemical signaling cascades, such as the protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) pathways, is necessary to induce long-term synaptic facilitation (LTF), a correlate of long-term memory (LTM).…

Training "Aplysia" with inedible food for a period that is too brief to produce long-term memory becomes effective in producing memory when training is paired with a nitric oxide (NO) donor. Lip stimulation for the same period of time paired with an NO donor is ineffective. Using qPCR, we examined molecular correlates of brief training…

Memory reactivation is a process whereby cueing or recalling a long-term memory makes it enter a new active and labile state. Substantial evidence suggests that during this state the memory can be updated (e.g., adding information) and can become more vulnerable to disruption (e.g., brain insult). Memory reactivations can also prevent memory decay…

We compared the long-term effects of generating questions by learners with answering questions (i.e., testing) and restudying in the context of a university lecture. In contrast to previous studies, students were not prepared for the learning strategies, learning content was experimentally controlled, and effects on factual and transfer knowledge…

Purpose: The nature of the relationship between memory and sentence comprehension in school-age children with developmental language disorder (DLD) has been unclear. We present a novel perspective that highlights the relational influences of fluid intelligence, controlled attention, working memory (WM), and long-term memory (LTM) on sentence…

Attentional refreshing allows the maintenance of information in working memory and has received growing interest in recent years. However, it is still ill-defined and several proposals have been put forward to account for its functioning. Among them, some proposals suggest that refreshing relies on the retrieval of knowledge from semantic…

A fundamental question for human memory research relates to the role of attention during the binding of distinct components into an integrated representation. A number of important differences exist between the working memory and episodic memory literature in terms of methodological implementation and empirical outcomes. For instance, episodic…

Replication of machine learning experiments can be a useful tool to evaluate how both "modeling" and "experimental design" contribute to experimental results; however, existing replication efforts focus almost entirely on modeling alone. In this work, we conduct a three-part replication case study of a state-of-the-art LSTM…

Abilities to encode and remember events in their spatiotemporal context (episodic memory) rely on brain regions that mature late during childhood and are supported by sleep. We compared the temporal dynamics of episodic memory formation and the role of sleep in this process between 62 children (8-12 years) and 57 adults (18-37 years). Subjects…

Thanks to unprecedented advances in brain science, we know more about the brain today than ever before. But what does that science tell us about how we learn? How can we capture the power of neuroscience research so that it benefits our students? Judy Willis and Malana Willis answer these questions with clarity and insight, translating recent…

We examined the contribution of a major predictor of basic literacy ability--phoneme awareness--to individual differences in two arithmetic computation tasks: a speeded task consisting of simple computation problems (arithmetic fluency) and an untimed, more complex computation task involving multi-digit operands (numerical operations). The…

Web-based technology has evolved to include interactive software that allows learners to prepare for real-life situations in the workforce. Educators and learners perceive interactive software, such as web-based scenarios, as a tool to support instructional content. Knowledge acquisition, enjoyment, and group discussions are just a few attributes…

Self-derivation of new factual knowledge through integration of separate episodes of learning is one means by which children build knowledge. Content generated in this manner becomes incorporated into the knowledge base and is retained over time; successful self-derivation predicts academic achievement. Yet the component processes on which…

Longstanding gaps between the reading achievement of English learner (EL) students and native English speakers highlight the need for evidence-based reading interventions validated for EL students. This study compared the efficacy of two flashcard-based interventions, incremental rehearsal (IR) and strategic incremental rehearsal (SIR), for…

Directed forgetting tasks instruct people to forget targeted memoranda. In the context of working memory, people attempt to forget representations that are currently held in mind. Here, we evaluated candidate mechanisms of directed forgetting within working memory, by (a) testing the influence of articulatory suppression, a rehearsal-reducing and…