Recognition memory deficits, even after short delays, are sometimes observed following hippocampal damage. One hypothesis links the hippocampus with processes in updating contextual memory representation. Here, we used fornix transection, which partially disconnects the hippocampal system, and compares the performance of fornix-transected monkeys…

Norepinephrine (NE) is a key modulator of synaptic plasticity in the hippocampus, a brain structure crucially involved in memory formation. NE boosts synaptic plasticity mostly through initiation of signaling cascades downstream from beta (ß)-adrenergic receptors (ß-ARs). Previous studies demonstrated that a ß-adrenergic receptor agonist,…

Previous studies have shown that zinc deficiency leads to apoptosis of neuronal precursor cells in vivo and in vitro. In addition to the role of p53 as a nuclear transcription factor in zinc deficient cultured human neuronal precursors (NT-2), we have now identified the translocation of phosphorylated p53 to the mitochondria and p53-dependent…

Children living in low-resource settings are at risk for failing to reach their developmental potential. While the behavioral outcomes of growing up in such settings are well-known, the neural mechanisms underpinning poor outcomes have not been well elucidated, particularly in the context of low- and middle-income countries. In this study, we…

The first 1,000 days of life are a critical window of vulnerability to exposure to socioeconomic and health challenges (i.e. poverty/undernutrition). The Brain Imaging for Global Health (BRIGHT) project has been established to deliver longitudinal measures of brain development from 0 to 24 months in UK and Gambian infants and to assess the impact…

Neuroscience offers insight into how we learn. Understanding how to leverage neural development pathways is of interest in teaching because the circuits in the brain respond to effective pedagogical practice; therefore, the role of the teacher is critical. Neuroscientific studies (Damasio in The feeling of what happens: body, emotion and the…

Dyslexia is a neurological language-based learning disability. Several legislative bills related to dyslexia have recently been introduced in the United States so dyslexia can be understood and interventions in reading instruction can be provided. Studies have shown measurable improvements in the language areas of the brain's left hemisphere after…

Although the world is changing rapidly, young people's developmental trajectory has remained the same. Just as in the past, today's young adolescents with still-developing prefontal cortexes are malleable, impulsive, and impressionable. But Phyllis Fagell identifies three areas where today's tweens are different from those of the past. They are…

Purpose: Retrieval practice has been found to be a powerful strategy to enhance long-term retention of new information; however, the utility of retrieval practice when teaching young children new words is largely unknown, and even less is known for young children with language impairments. The current study examined the effect of 2 different…

This study examined functional changes longitudinally over 2 years in neural correlates associated with working memory in youth with and without autism spectrum disorder, and the impact of increasing cognitive load. We used functional magnetic resonance imaging and a visuo-spatial 1-back task with four levels of difficulty. A total of 14 children…

Recent ERP research with adults has shown that the online processing of subject-verb (S-V) agreement violations is mediated by the relative perceptual salience of the violation (Dube et al. 2016). These findings corroborate infant perception research, which has also shown that perceptual salience influences infants' sensitivity to grammatical…

Several theoretical proposals tried to account for the meaning open-endedness of metaphors in literature and for the effortful process they trigger in readers. However, very few experiments have tackled the neurophysiological underpinnings of literary metaphor. Here we used Event-Related brain Potentials (ERPs) to explore the temporal dynamics of…

The purpose of this study was to investigate the effects of brain-based learning approach on study habits and test anxiety among first year preparatory school students with learning disabilities. 60 students participated in the present study. Each student participant is of low achievement scores on one or more standardized tests or subtests within…

The views that gender and language are related each other has been reviewed from at least two different disciplines: sociolinguistics and psychology. From the first discipline, it has been concluded that gender and language has no natural relationship for it is cultural values that shape genderlect. From the second discipline, it has been…

New advances in neurobiology are revealing that brain development and the learning it enables are directly dependent on social-emotional experience. Growing bodies of research reveal the importance of socially triggered epigenetic contributions to brain development and brain network configuration, with implications for social-emotional…