Inhibitory control (IC) emerges in infancy, continues to develop throughout childhood and is linked to later life outcomes such as school achievement, prosocial behavior, and psychopathology. Little, however, is known about the neural processes underpinning IC, especially in 2-year-olds. In this study, we examine functional connectivity (FC) in…

Hemispheric lateralisation is a fundamental principle of functional brain organisation. We studied two core cognitive functions--language and visuospatial attention--that typically lateralise in opposite cerebral hemispheres. In this work, we tested both left- and right-handed participants on lexical decision-making as well as on symmetry…

Reading disorders are common in children and can impact academic success, mental health, and career prospects. Reading is supported by network of interconnected left hemisphere brain regions, including temporo-parietal, occipito-temporal, and inferior-frontal circuits. Poor readers often show hypoactivation and reduced gray matter volumes in this…

Recent data reveal that the thalamic nucleus reuniens (RE) has a critical role in the extinction of conditioned fear. Muscimol (MUS) infusions into the RE impair within-session extinction of conditioned freezing and result in poor long-term extinction memories in rats. Although this suggests that RE inactivation impairs extinction learning, it is…

Dopamine participates in encoding memories and could either encode rewarding/aversive value of unconditioned stimuli or act as a novelty signal triggering contextual learning. Here we show that intraperitoneal injection of the dopamine D1/5R antagonist SCH23390 impairs contextual fear conditioning and tone-shock association, while intrahippocampal…

This dissertation investigates the neural bases and development of displacement, which is a language property that allows us to communicate about situations outside the "here-and-now." One way to displace from our immediate environment is to project ourselves into the here-and-now point of an alternative actuality. Another form of…

The brain must strike a balance between reliable information processing and adaptation to an ever-changing environment. At a gross anatomical level, the brain's wiring diagram is believed to be relatively set after development. Therefore, a fundamental question arises: how does stereotyped wiring lead to flexible dynamics, computation, and…

Evidence from rodent studies highlights the mother as a safety cue that regulates fear and biology. However, when infant rats are exposed to rough maternal care (i.e., threat), their brains show atypical patterns of activity in response to maternal cues. In humans, childhood adversity (i.e., international adoption, involvement with Child…

Administering anodal transcranial direct current stimulation at the left dorsal premotor cortex (PMd) but not right PMd throughout the repetitive practice of three novel motor sequences resulted in improved offline performance usually only observed after interleaved practice. This gain only emerged following overnight sleep. These data are…

Purpose: Amplitude modulations (AMs) are important for speech intelligibility, and deficits in speech intelligibility are a leading source of impairment in childhood listening difficulties (LiD). The present study aimed to explore the relationships between AM perception and speech-in-noise (SiN) comprehension in children and to determine whether…

What is the relationship between literacy skills and implicit learning? To address previous mixed findings, we compared school-aged readers, typical (CON, n = 54) and with dyslexia (DYS, n = 53), in relation to their performance on a serial reaction time task. For the first time, we also included an isolated spelling deficit group (ISD, n = 30) to…

Phonological awareness (PA) is an important predictor and outcome of reading. Yet, little is known about the reciprocal relation between PA and reading across development without consistent reading experience (e.g., as a result of limited access to quality education and late enrolment in school). We tested the hypothesis that variable reading…

Research Findings: Early digital experience (e.g. screen time and digital use) is believed to impact children's brain development, functionally and structurally, but this impact has not been systematically reviewed. In this scoping review, we synthesized and evaluated 33 collected studies on children's digital use (ages 0-12) and their associated…

The CVI Center at Perkins created a new CVI (cerebral or cortical visual impairment) assessment tool called The CVI Protocol that is rooted in research and based on 16 visual behaviors and compensatory strategies. The CVI Protocol leads a teacher of students with visual impairments (TVI) through evaluating how a student is impacted by CVI and…

This study investigated whether transcranial direct current stimulation (tDCS) targeting the inferior frontal gyrus (IFG) can alter the thinking process and neural basis of creativity. Participants' performance on the compound remote associates (CRA) task was analyzed considering the semantic features of each trial after receiving different tDCS…