This research brief describes key takeaways for researchers from a rigorous evaluation of Single Stop, a college basic needs intervention. The study team faced challenges with student take-up of Single Stop services such as application support, tax services, and case management in a randomized control trial of Single Stop that was conducted across ten colleges in Colorado and North Carolina. The research brief identifies four lessons learned and describes how the study experiences illustrate each lesson. These include: (1) Consider trade-offs between studying new programs and more-established programs. (2) Consider study designs that do not interfere with key outreach practices recommended for the successful delivery of services. (3) Focus studies of time-intensive interventions on the groups of students who are most likely to need supports. (4) Ensure that interventions are accessible to the students and college staff who will engage with them.