Even though quality management initiatives are crucial for enhancing the performance of Higher Education Institutions (HEIs), there is a lack of research on how the academic accreditation process influences it. This study aims to assess the impact of quality management initiatives on HEI performance, in addition to exploring the mediating role of academic accreditation. Using a quantitative research approach, from January 15, 2023, to May 15, 2023, we collected data from 370 participants employed in 76 HEIs located in the United Arab Emirates (UAE). The data collection employed a snowball sampling technique, utilizing survey questionnaires, and the analysis was performed using SmartPLS 4 software. The results show that quality management initiatives are pivotal in improving HEIs' performance. In addition, academic accreditation, as an intermediary, amplifies the relationship between these initiatives and institutional performance. The findings imply that HEIs need to focus on quality management initiatives particularly leadership commitment, effective communication, and professional development to achieve academic accreditation as well as to enhance overall institutional performance.