Due to advancements in technology and the demand for flexible instruction, online educational opportunities are increasing. However, instructors still need guidance to teach students effectively in different types of online courses. This article provides context- and delivery-specific guidelines for those teaching asynchronous, synchronous, and blended online courses. The authors explain the three types of online courses and discuss the context-specific guidelines that instructors need to understand to teach their students effectively online. Moreover, they provide suggestions for instruction and assessment and share diverse materials and activities to facilitate the effectiveness of online teaching.