The progression of "Industry 4.0" has engendered substantial generational evolutions in the requirements for talents. In the absence of "Education 4.0", the realization of "Industry 4.0" remains unfeasible. The transformation of higher vocational education constitutes a pivotal juncture in the continuous propulsion of the industrialization process. Against the backdrop of "Industry 4.0", researchers concentrate their attention on the classroom instruction within China's higher vocational education. Their objective is to probe into the trajectory of transformation, the focal concerns of classroom instruction, and the means of effectuating such transformations. Researchers maintain that classroom instruction in China's higher vocational education, being an essential arena for talent cultivation, ought to take the emotional experiences within the classroom, the transformation of teaching paradigms, the development of innovative education, and the cultivation of innovative thinking as its guiding orientations. Through "bottom-up" and "inside-out" endogenous transformations, the closed-loop of higher vocational classroom instruction should be disrupted. The goals and directions of talent cultivation should be adjusted dynamically, with equal emphasis placed on classroom instruction and practical applications. Actively, the realization of the strategic objective of "Made in China 2025" should be facilitated to enhance the universal literacy.