Almost all commercial quadrupole ICP-MS instruments use collision/reaction cells to either attenuate spectral interferences or shift the analyte of interest to an interference-free "m/z" (e.g., by O addition). A laboratory practical was developed to introduce the students to the basic operating principles of ICP-MS using a hands-on…

Imines are important in biological chemistry and as intermediates in organic synthesis. An experiment for introductory undergraduate organic chemistry is presented in which benzaldehyde was condensed with "p"-methoxyaniline in toluene to give 4-methoxy-"N"-(phenylmethylene)benzenamine. Water was removed by azeotropic…

Raman spectroscopy is a powerful experimental technique, yet it is often missing from the undergraduate physical chemistry laboratory curriculum. Tetrachloromethane (CCl[subscript 4]) is the ideal molecule for an introductory vibrational spectroscopy experiment and the symmetric stretch vibration contains fine structure due to isotopic variations…

The molecular basis of evolution is an important and challenging concept for students to understand. In a previous article, we provided some of the scientific background necessary to teach this topic. This article features a series of laboratory activities demonstrating that molecular events can alter the genomes of organisms. These activities are…

Industrial purification of biomolecules is commonly based on a sequence of chromatographic processes, which are adapted slightly to new target components, as the time to market is crucial. To improve time and material efficiency, modeling is increasingly used to determine optimal operating conditions, thus providing new challenges for current and…

Presents an examination of the buoyancy principle which can serve as a simple but rigorous illustration of a falsification test that not only clears up a possible misconception but also points the way to a number of practical uses of buoyancy measurements that have not generally been recognized. (MVL)

Discusses the mechanism and the change of pH during the reaction. Notes that a dramatic rise in pH occurs when the reaction nears completion. Evaluates theories by other authors. (MVL)

Science educators often assume and expect that students who are actively engaged in scientific inquiry should develop more accurate understandings of science and the construction of scientific knowledge. However, this assumption, while intuitive, has not been validated. This paper reports on a study that sought to determine the impact of an 8-week…

Explains an activity that allows students to visualize antigen-antibody type reactions and learn about antibodies and antigens without performing blood typing tests. Provides directions for students and a comparison chart of a blood typing simulation with procedure which is based on the reactions of certain ionic solutions when mixed. (RT)

Presents a device to illustrate the concepts of entropy of mixing and the contribution of one term in the Gibb's equation. Notes the device is relatively easy to construct and provides a visual demonstration on diffusion. (MVL)

Classroom discussion of scientific articles can be an effective means of teaching scientific principles and methodology to both undergraduate and graduate science students. The availability of classic papers from the American Physiological Society Legacy Project has made it possible to access articles dating back to the early portions of the 20th…