Prepared as a self-instructional tool for anyone interested in indexing documents from their titles using the NEsted PHrase Indexing System (NEPHIS), this manual introduces, defines, and provides guidelines for the use of this computer-assisted indexing system. The objectives of the system are outlined, the NEPHIS computer program and input formats are discussed, and a detailed set of NEPHIS implementation rules covers such topics as the standardization of titles, potential errors, and access points. A NEPHIS implementation sheet, a description of a project in which NEPHIS was implemented on a set of over 3,000 Canadian government documents, and a list of bibliographic references are appended. A NEPHIS index sample page is also attached. (JL)