Cycloadditions in combination with multicomponent reactions are among the most valuable synthetic tools used by organic chemists to construct cyclic and heterocyclic compounds in a straightforward way. Although cycloadditions, such as the Diels--Alder reaction, are mainly covered in basic and advanced organic courses for undergraduate students,…

Optimization of experimental conditions in chromatography is recognized as a wear-and-tear process involving hundreds of experiments in order to maximize the number of separated compounds for each sample. The critical thinking skills and practices entailed cannot be achieved with students in a conventional lecture class. This report provides a…

Friedel-Crafts alkylation reactions using a curated set of alcohols provide students with the opportunity to combine the study of electrophilic aromatic substitution with carbocation rearrangements. In this experiment students may be presented with up to nine alcohols that yield six products, all synthesized under identical reaction conditions.…

The autumnal leaf color change is a familiar phenomenon to most students living in temperate climate zones. The extraction and analysis of the pigments of the autumn leaves provide an engaging way to study the phenomenon utilizing both simple as well as more sophisticated analytical methods. In this laboratory experiment, students extract the red…

Undergraduate physics laboratory exercises are very important in shaping students' attitude to science, especially for future teachers. Recently, it is necessary to look for ways to easily create large quantities of experimental sets, not only for institutional use, but also for sets that can be produced in large quantities and distributed for use…

This report describes a laboratory experiment for an undergraduate-level inorganic chemistry or biochemistry course involving the study of the kinetics of the catecholase activity of a synthetic nickel­(II)-oximate complex. A model substrate, 3,5-di-tert-butylcatechol(DBC), undergoes aerobic oxidation to 3,5-di-tert-butylbenzoquinone (DBQ) in the…

A laboratory experiment was developed to introduce undergraduate chemistry students to the chemical characterization of agroindustrial waste extracts by gas chromatography-mass spectrometry (GC--MS). The students prepared hexane and dichloromethane extracts from black pepper ("Piper nigrum" L.) waste. GC--MS analysis revealed the…

Oxidation reactions are critical components of the synthetic toolbox taught to undergraduate students during introductory organic chemistry courses. However, the oxidation reactions discussed in the undergraduate curriculum are often outdated as many organic chemistry textbooks emphasize chromium-based oxidants that are no longer in regular use by…

Organic chemistry students often struggle with reaction mechanisms, particularly in how they are proposed and justified. In this activity targeting second year organic undergraduates, students used infrared spectroscopy (IR) to track the reaction progress of two distinct aldol reactions and used polarimetry to analyze the stereoselectivity of…

Chemistry in water is an emerging field that fulfills the fifth principle of green chemistry: replacing toxic organic solvents with their benign counterparts. Although some pharmaceutical industries have developed and adopted chemistry in water, its implementation in teaching laboratories is still limited. Therefore, we have designed an experiment…

This work presents a homemade multirole 3D-printed modular spectrometer(MPMS), which can be easily assembled like bricks and expanded with several modules to measure different types of spectra, such as UV-vis absorption, fluorescence emission, flame emission/absorption, glow discharge, and even Raman spectra. The spectrometer is designed to be…

Microplastics have been detected in most ecosystems around the world. They affect the environment and organisms in it, including humans and possibly their health. Hence, the analysis of microplastic occurrence in the environment is highly relevant. However, there are only a few practical and easy-to-implement methods published for school use, and…

An experiment for the undergraduate physical chemistry laboratory is described in which the Raman spectrum of liquid "para"-difluorobenzene is recorded and assigned. A density functional theory (DFT) calculation of the 30 normal modes of the molecule is undertaken using computational chemistry software. Students use group theory to…

A new undergraduate organic laboratory experiment has been developed and implemented for the Ugi three-component synthesis of the topical anesthetic lidocaine with excellent atom economy. Paraformaldehyde, diethylamine, and 2,6-dimethylphenyl isocyanide were combined and conveniently stirred at room temperature for a week in methanol with acetic…

Millions of people do not have access to clean drinking water; thus, cost-efficient water treatment systems are vital. Chemists, environmentalists, technicians, and engineers will be the professionals making breakthroughs in this industry. This laboratory experiment aims to introduce undergraduate students to the removal of pollutants from water…