The purpose of the study was to explore the issues and barriers in usability and accessibility of Open Education Resources and MOOCs by the students with special needs in distance learning. The study also highlighted the problems and issues faced by the designers, developers, instructors and administrators while designing, developing, offering and conducting the MOOCs and developing OERs. The study was descriptive in nature and survey method was used to collect the data. It was limited to students with hearing impairment, visual impairment and physically handicapped enrolled in Open and Distance Learning system. The researcher found that large numbers of students with special needs were concerned with usability and accessibility because they were not familiar with the OERs, MOOCs and technologies associated. Special need students pointed out the problems/issues in using assistive technologies while navigating in the MOOC environment, in automated assessment and the process of engaging with fellow students through forum posts and collaborative group work. It is recommended by the researcher that these problems and issues may be considered while developing e-content, conducting online classes and assessment in MOOCs and OERs with maximum usability and accessibility issues.