Histone acetylation, catalyzed by e, has emerged as a promising therapeutic strategy in Alzheimer's disease (AD). By longitudinally characterizing spatial memory at 3, 6, and 9 mo of age, we show that acute activation and inhibition of the histone acetyltransferase PCAF remediated memory impairments in 3xTG-AD mice in an age-related bidirectional…

Children's spatial mapping starts out particularly sensitive to 3D wall-like boundaries and develops over early childhood to flexibly include other boundary types. This study investigated whether spatial boundaries influence children's episodic memory, as in adults, and whether this effect is modulated by boundary type. Eighty-one Korean children…

This study compared physical and digital models of a scientific topic in order to determine representational competence, short- and long-term cognition, and the extent to which physical or digital interfaces enhance spatial ability. The DNA molecule was used as a representative spatial topic to investigate conceptual and spatial understanding.…

Mental rotation, a crucial aspect of spatial cognition, can be improved through repeated practice. However, the long-term effects of combining training with non-invasive brain stimulation and its neurophysiological correlates are not well understood. This study examined the lasting effects of a 10-day mental rotation training with high-definition…

Researchers agree that both domain-general skills and domain-specific skills contribute to mathematics knowledge, but questions arise as to which skills can and should be trained to improve children's learning outcomes. In this article, we synthesize research on training three domain-general constructs in early childhood (patterning skills,…

Spatial skills are critical for learning in STEM areas and are affected by spatial anxiety and working memory. Prior work also showed that there are interaction effects between spatial anxiety and verbal working memory (WM) on spatial skills, such that the negative relation between spatial anxiety and spatial skills is stronger among higher- than…

The relation between perceptual and conceptual knowledge is a longstanding research question in developmental psychology. Here we tested children's dependence on figurative information with a reaction time/accuracy task. A sample of 151 children from 5 to 10 years were assessed from two multicultural and multiracial schools in the London (UK)…

Identifying factors that contribute to spatial thinking is of great interest given links between spatial thinking and success in Science, Technology, Engineering, and Mathematics (STEM) disciplines. Working memory has been found to be predictive of spatial thinking but little research has explored other components of executive function (i.e.,…

Three-dimensional (3D) scanning and printing technology has allowed for the production of anatomical replicas at virtually any size. But what size optimizes the educational potential of 3D printing models? This study systematically investigates the effect of model size on nominal anatomy learning. The study population of 380 undergraduate…

Development dyslexia (DD) is a common language disorder, that significantly affects children. Despite having ordinary intelligence, dyslexic people struggle with reading, writing, and comprehension in their native tongue. It is still unclear whether dyslexic kids have difficulties with visuo-spatial working memory. Using meta-analysis, this gap…

Valued-based decision-making has been studied for decades in myriad topics such as consumer spending and gambling, but very rarely in spatial navigation despite the link between the two being highly relevant to survival. Furthermore, how people integrate episodic memories, and what factors are related to the extent of memory integration in…

This study investigated to what extent people can develop global spatial representations of a multiroom environment through one-shot physical walking between rooms. In Experiment 1, the participants learned objects' locations in one room of an immersive virtual environment. They were blindfolded and led to walk to a testing position either within…

Some theories have proposed that autistic individuals have difficulty learning predictive relationships. We tested this hypothesis using a serial reaction time task in which participants learned to predict the locations of a repeating sequence of target locations. We conducted a large-sample online study with 61 autistic and 71 neurotypical…

In this paper, we investigated the contribution of both cognitive and affective factors to mathematical skills. In particular, we looked at the protective role of self-concept for mathematical learning and performance. In a field study, we tested the relation of math self-concept and short-term visuo-spatial working memory to the mathematical…

During the preschool years, children are simultaneously undergoing a reshaping of their mental number line and becoming increasingly sensitive to the social norms expressed by those around them. In the current study, 4- and 5-year-old American and Israeli children were given a task in which an experimenter laid out chips with numbers (1-5),…