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Jennifer L. Proper; Haitao Chu; Purvi Prajapati; Michael D. Sonksen; Thomas A. Murray – Research Synthesis Methods, 2024
Drug repurposing refers to the process of discovering new therapeutic uses for existing medicines. Compared to traditional drug discovery, drug repurposing is attractive for its speed, cost, and reduced risk of failure. However, existing approaches for drug repurposing involve complex, computationally-intensive analytical methods that are not…
Descriptors: Network Analysis, Meta Analysis, Prediction, Drug Therapy
Xu, Ziqian; Hai, Jiarui; Yang, Yutong; Zhang, Zhiyong – Grantee Submission, 2022
Social network data often contain missing values because of the sensitive nature of the information collected and the dependency among the network actors. As a response, network imputation methods including simple ones constructed from network structural characteristics and more complicated model-based ones have been developed. Although past…
Descriptors: Social Networks, Network Analysis, Data Analysis, Bayesian Statistics
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Efthimiou, Orestis; White, Ian R. – Research Synthesis Methods, 2020
Standard models for network meta-analysis simultaneously estimate multiple relative treatment effects. In practice, after estimation, these multiple estimates usually pass through a formal or informal selection procedure, eg, when researchers draw conclusions about the effects of the best performing treatment in the network. In this paper, we…
Descriptors: Models, Meta Analysis, Network Analysis, Simulation
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Uhlmann, Lorenz; Jensen, Katrin; Kieser, Meinhard – Research Synthesis Methods, 2017
Network meta-analysis is becoming a common approach to combine direct and indirect comparisons of several treatment arms. In recent research, there have been various developments and extensions of the standard methodology. Simultaneously, cluster randomized trials are experiencing an increased popularity, especially in the field of health services…
Descriptors: Bayesian Statistics, Network Analysis, Meta Analysis, Randomized Controlled Trials