The Wilson cloud chamber, invented in 1911 by Scottish physicist Charles Wilson, is a remarkably simple and effective charged particle detector. Cloud chambers were used regularly in particle physics experiments for decades, until being supplanted by bubble chambers. In this article, we describe a lab activity that is suitable for…

Using crystal structure data, site directed mutagenesis, and real-time kinetic assays, students designed, expressed, and purified engineered mutants of human insulin-degrading enzyme (IDE). Students designed their own IDE mutants following "in silico" analysis, used inverse PCR to generate mutant plasmid expression constructs, expressed…

Raman scattering is a powerful tool for revealing the vibrations of molecules, but as a nonlinear optical phenomenon, its signals can change via mechanisms like resonance enhancement that have no direct analogue in infrared spectroscopy. In this work, complementary measurements conducted on 4-nitrophenol and its conjugate base allow students to…

Measurement uncertainty is a key topic in the university physics laboratory curriculum. In this study, we investigate students' ability to draw conclusions from measurement data and reasoning about measurement uncertainty in inquiry labs. This investigation centres around a task where students conclude whether measurements from two experiments…

This paper reports the quantification of Ca, Mg, and Fe as micronutrients in different vegetables (spinach, sugar beets, and carrots) from raw and processed samples. Simple extraction procedures, titrations, and spectrophotometric analysis were used to determine the amounts of micronutrients before and after cooking. From the obtained results, an…

This communication describes an updated experiment of peptide synthesis, involving determination of the loading capacity of a Fmoc-protected amino functionalized resin using UV-vis spectroscopy and a subsequent synthesis of a dipeptide in order to exemplify the experimental solid-phase synthesis procedure as an alternative technique in organic…

Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…

Cycloadditions in combination with multicomponent reactions are among the most valuable synthetic tools used by organic chemists to construct cyclic and heterocyclic compounds in a straightforward way. Although cycloadditions, such as the Diels--Alder reaction, are mainly covered in basic and advanced organic courses for undergraduate students,…

[This paper is part of the Focused Collection on Instructional labs: Improving traditions and new directions.] This manuscript presents a case study of an introductory physics student who, during the remote learning conditions imposed during the COVID-19 pandemic, found inspiration within a new, open-inquiry, project-based, laboratory curriculum…

When thinking about measurement uncertainty in a laboratory experiment that features quantum mechanical effects, it is important to consider both the physical principles of underlying quantum theory (e.g., the uncertainty due to quantum mechanical superposition states) as well as the limitations of the measurement (e.g., the spread in outcomes due…

Even though physical experiments are mandatory in science education, there has been an increasing demand for virtual experiments. This research aimed to investigate the impact of virtual experiments compared to physical experiments on students' conceptual understanding of chemical kinetics concepts. To achieve this, a two-phase explanatory…

Undergraduate physics laboratory exercises are very important in shaping students' attitude to science, especially for future teachers. Recently, it is necessary to look for ways to easily create large quantities of experimental sets, not only for institutional use, but also for sets that can be produced in large quantities and distributed for use…

This paper presents a series of experiments that focus on light polarization and polarimetry. Such experiments were conducted with the use of commercial Polaroids, light sensors, and laser pointers, and were designed for an undergraduate food science students physics lab.

We describe a project implemented in the honors section of an upper-level analytical chemistry undergraduate course, in which students designed an experiment to compare the performance of two analytical techniques to determine the amount of ascorbic acid in a commercial sample. This project designed for 18 students is composed of three stages. In…

This report describes a laboratory experiment for an undergraduate-level inorganic chemistry or biochemistry course involving the study of the kinetics of the catecholase activity of a synthetic nickel­(II)-oximate complex. A model substrate, 3,5-di-tert-butylcatechol(DBC), undergoes aerobic oxidation to 3,5-di-tert-butylbenzoquinone (DBQ) in the…