Keto-enol tautomerization is paramount to understanding the mechanisms involved in many organic reactions and biochemical transformations. Isomerization of an enol to a carbonyl compound is typically introduced during the discussion of the acid-catalyzed electrophilic addition of water to alkynes. The tautomerization of carbonyl compounds to enol…

Computational thinking (CT) is becoming increasingly important for K-12 science education, thus warranting new integrations of CT and science content. This intervention study integrated CT through unplugged, or handwritten, algorithmic explanations of natural selection. As students investigated natural selection in varying contexts (specific and…

Ion transport, involving the diffusion and migration of ions within the electrolyte, stands as a fundamental concept in electrochemistry and serves as the driving force for electrochemical reactions. Electric double layers are critical in the fields of electrochemical energy storage and chemical conversion, constituting a central focus of…

The study and analysis of enzymatic reactions are essential for characterizing various biological systems. As part of these procedures, it is important to understand how to quantify the biological activity of these proteins in terms of enzymatic activity. This work proposes a general equation for determining enzymatic activity based on…

Background/purpose: Computational Thinking is a content that has been integrated into primary education curricula in several countries. Its proper integration into education is not limited to its inclusion in the educational curricula, and teachers and pre-service teachers must develop the necessary knowledge to integrate it into their practices…

Synthesis of (Z)-alkenes is challenging because the (E) stereoisomers are usually more stable. Energy transfer photocatalysis has emerged as an efficient strategy for (E) [right arrow] (Z) alkene isomerization. We report the development of an advanced undergraduate laboratory experiment that introduces students to contemporary organic…

This short paper presents an educational approach to teaching three popular methods for encoding DNA sequences: one-hot encoding, binary encoding, and integer encoding. Aimed at bioinformatics and computational biology students, our learning intervention focuses on developing practical skills in implementing these essential techniques for…

Background/purpose. 21st-century skills are essential across all aspects of life in the modern era. Pre-service elementary school teachers must also develop computational thinking skills as part of the problem-solving process--one of the most critical 21st-century competencies. These skills are critical in science learning and serve as fundamental…

The role of computation in science is ever-expanding and is enabling scientists to investigate complex phenomena in more powerful ways and tackle previously intractable problems. The growing role of computation has prompted calls to integrate computational thinking (CT) into science instruction in order to more authentically mirror contemporary…

Virtual Labs (vLabs) have been gaining popularity in high school and undergraduate education, but there are few studies looking at their use in graduate-level courses. In this study, we investigated the use of six Labster vLabs assigned as homework in a graduate-level in-person Genomic Methodologies course at the University of Toronto. This course…

Computational models are employed to study and respond to pressing environmental issues such as groundwater contamination. This use of computational models, which often involves algorithms and uncertainty that are hidden to the public, has implications for environmental science literacy. This study applies a design-based research approach to…

To make sense of our interconnected and algorithm driven world, students increasingly need proficiency with computational thinking (CT), systems thinking (ST), and computational modeling. One aspect of computational modeling that can support students with CT, ST, and modeling is testing and debugging. Testing and debugging enables students to…

Enzymes are nature's catalysts, mediating chemical processes in living systems. The study of enzyme function and mechanism includes defining the maximum catalytic rate and affinity for substrate/s (among other factors), referred to as enzyme kinetics. Enzyme kinetics is a staple of biochemistry curricula and other disciplines, from molecular and…

Calculating analytical uncertainties as a part of method validation is a relevant aspect of field and laboratory practices in instrumental analytical chemistry subjects, which usually require complex algorithms. This work describes the development and didactic use of an automatic and straightforward informatics tool, implemented in an Excel macro,…

Knowledge-producing practices in sciences and engineering increasingly use computational means for modeling and working with data. Despite consensus regarding the importance of computational thinking in science and engineering, scholars differ in conceptualization of the primary purposes and role of its integration in K-12 science (Kafai &…