The National Institute of Mental Health created the National Database for Autism Research (NDAR) to accelerate autism knowledge through data sharing and collaboration. However, our experience using NDAR reveals systematic challenges across several aspects of data submission, selection, management, and analysis that limit utility of this resource.…

Characteristics of autism research were examined in the survey of a subset of studies (1971-1982). Results indicated inadequacies of subject selection procedures and omission of important descriptive information. The authors stress the need for increased use of objective, quantitative measures of diagnosis and assessment of intellectual abilities.…

This paper reviews the methodology in articles that have reported structural neuroimaging or neuropsychological data in adolescent patients with schizophrenia. Identification of methodological issues led to the finding that, at present, no conclusions can be made regarding the presence or absence of neuropsychologic dysfunction or structural…

The sources of variability residing in the environment of individuals with autism and the implications for research studies are explored. Recommendations are provided for future research including research focusing on young children, on the methods needed to produce desirable outcomes, on relationships between behaviors, and on specific teaching…

This study provides support for a potential subclinical marker in the executive function domain of siblings (n=18, ages 8-18) of autistic individuals, compared to learning-disabled controls. No group differences in theory-of-mind abilities were found. The need to develop more sensitive measures is discussed. (Author/JDD)

Several different methodological approaches that have been used in studying language in children with autism are outlined. In classic studies, children with autism are compared to comparison groups typically matched on age, IQ, or mental age in order to identify which aspects of language are uniquely impaired in autism. Several methodological…

This commentary discusses the wide acceptance of and the expenditure of limited resources on unproven behavioral therapies for individuals with autism. Considerations that need to be reviewed before adopting a behavioral treatment are outlined, including the need to establish whether direct effects can be attributed to a treatment. (Contains 11…

This article comments on results of a study (EC 629 869) on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It discusses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains…

This article responds to comments (EC 629 869-70) on a study on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It addresses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains 6…

A review of the empirical research literature on Social Stories[TM] is presented, including a descriptive review and single-subject meta-analysis of appropriate studies. Examination of data suggests the effects of Social Stories[TM] are highly variable. Interpretations of extant studies are frequently confounded by inadequate participant…

Discusses sensory-perceptual abnormalities in people with autism from published firsthand accounts and existing psychological research evidence. A range of abnormalities, including hyper- and hyposensitivity, sensory distortion and overload, and multichannel receptivity and processing difficulties, are described and the limitations of clinical and…

This article reviews elements of a well-designed treatment study and evaluates the state of knowledge about comprehensive treatment programs for children with autism. Several suggestions are made for improving future studies, including more rigorous designs, searching for active ingredients of treatment programs, and measuring change. (Contains…

The possibility of differential sex proportions as a confounding factor in the Lovaas (1987) study is raised. It is argued that the chi-square analysis was inadequate and that the appropriate comparison should be made between the experimental and the control group using population data to estimate expected cell frequencies. (Author/CR)

This article analyzes outcome measures used in intervention research with young children with autism, including 72 reports evaluating specific intervention practices and 15 reports of complete intervention programs. Results indicate measurement of mediating variables is essentially absent in the evaluation reports and there is a lack of other…