NotesFAQContact Us
Collection
Advanced
Search Tips
Showing all 5 results Save | Export
Statistical Approaches to Adjusting Weights for Dependent Arms in Network Meta-Analysis
Peer reviewed Peer reviewed
Direct linkDirect link
Su, Yu-Xuan; Tu, Yu-Kang – Research Synthesis Methods, 2018
Network meta-analysis compares multiple treatments in terms of their efficacy and harm by including evidence from randomized controlled trials. Most clinical trials use parallel design, where patients are randomly allocated to different treatments and receive only 1 treatment. However, some trials use within person designs such as split-body,…
Descriptors: Network Analysis, Meta Analysis, Randomized Controlled Trials, Research Design
Get Real in Individual Participant Data (IPD) Meta-Analysis: A Review of the Methodology
Peer reviewed Peer reviewed
Direct linkDirect link
Debray, Thomas P. A.; Moons, Karel G. M.; van Valkenhoef, Gert; Efthimiou, Orestis; Hummel, Noemi; Groenwold, Rolf H. H.; Reitsma, Johannes B. – Research Synthesis Methods, 2015
Individual participant data (IPD) meta-analysis is an increasingly used approach for synthesizing and investigating treatment effect estimates. Over the past few years, numerous methods for conducting an IPD meta-analysis (IPD-MA) have been proposed, often making different assumptions and modeling choices while addressing a similar research…
Descriptors: Meta Analysis, Outcomes of Treatment, Research Methodology, Literature Reviews
An Introduction to Methodological Issues When Including Non-Randomised Studies in Systematic Reviews on the Effects of Interventions
Peer reviewed Peer reviewed
Direct linkDirect link
Reeves, Barnaby C.; Higgins, Julian P. T.; Ramsay, Craig; Shea, Beverley; Tugwell, Peter; Wells, George A. – Research Synthesis Methods, 2013
Background: Methods need to be further developed to include non-randomised studies (NRS) in systematic reviews of the effects of health care interventions. NRS are often required to answer questions about harms and interventions for which evidence from randomised controlled trials (RCTs) is not available. Methods used to review randomised…
Descriptors: Research Methodology, Research Design, Health Services, Workshops
Issues Relating to Confounding and Meta-analysis When Including Non-Randomized Studies in Systematic Reviews on the Effects of Interventions
Peer reviewed Peer reviewed
Direct linkDirect link
Valentine, Jeffrey C.; Thompson, Simon G. – Research Synthesis Methods, 2013
Background: Confounding caused by selection bias is often a key difference between non-randomized studies (NRS) and randomized controlled trials (RCTs) of interventions. Key methodological issues: In this third paper of the series, we consider issues relating to the inclusion of NRS in systematic reviews on the effects of interventions. We discuss…
Descriptors: Research Design, Randomized Controlled Trials, Intervention, Bias
Practicalities of Using a Modified Version of the Cochrane Collaboration Risk of Bias Tool for Randomised and Non-Randomised Study Designs Applied in a Health Technology Assessment Setting
Peer reviewed Peer reviewed
Direct linkDirect link
Robertson, Clare; Ramsay, Craig; Gurung, Tara; Mowatt, Graham; Pickard, Robert; Sharma, Pawana – Research Synthesis Methods, 2014
We describe our experience of using a modified version of the Cochrane risk of bias (RoB) tool for randomised and non-randomised comparative studies. Objectives: (1) To assess time to complete RoB assessment; (2) To assess inter-rater agreement; and (3) To explore the association between RoB and treatment effect size. Methods: Cochrane risk of…
Descriptors: Risk, Randomized Controlled Trials, Research Design, Comparative Analysis