ICH-GCP guidelines have provided international ethical, scientific, quality standards for designing, conducting, recording, and reporting of clinical trials, and are hugely popular in the region. Recent revisions to its guidance; ICH-GCP; E6 (R3) have brought significant changes in both structure and content from its predecessor, affecting every…

The growing understanding of the deleterious effects of childhood trauma has led policymakers to encourage the integration of trauma-informed system approaches into educational settings. The National Childhood Traumatic Stress Network has created a framework that integrates trauma-responsive school policies, practices, and programs at each tier of…

Background: This paper presents the baseline characteristics and their moderators in the Healthy Learning Mind (HLM)-- school-based cluster-randomized controlled trial. Objectives: The paper evaluates the state of various measures of well-being, their moderators and how these results compare to national and global norms/population studies.…

This review aims to systematically summarize existing evidence to determine the effectiveness of cognitive-based interventions (CBIs) on psychological health and well-being among parents of children with developmental disabilities (DD). Six databases were searched to identify eligible randomized controlled trials (RCTs) from their inception to…

Perfectionism has adverse impacts on mental health and academic outcomes. We evaluated a 5-lesson classroom intervention for young adolescents delivered by teachers for impact on perfectionism, well-being, self-compassion, academic motivation and negative affect, at post-intervention and 3-month follow-up. Classes (N = 636 students, M[subscript…

The primary objective of the proposed systematic review is to answer the following research question: do parenting programmes for parents of adolescents impact adolescent mental health outcomes, positive development and the parent-adolescent relationship? This will be achieved by systematically searching for and synthesising the extant evaluation…

Background: It has become increasingly important to shift education research and programming from a deficit focused perspective to a positive youth development perspective in order to identify and promote factors that support students' positive functioning and outcomes. One outgrowth of positive youth development is Positive Mental Health (PMH),…

Objective: Mindfulness-based interventions have been shown to have psychological benefits in college students. We explored the effects of an academic Seminar on Compassion on student psychological health. Participants: Forty-one participants (14 male, 27 female, mean age 19.8 ± 1.4 years) were assessed pre- and post- spring semesters 2013 and…

For the past 25 years, I have led multiple group-randomized trials, each focused on a specific underserved population of youth and each one evaluated health effects of complex interventions designed to prevent high-risk behaviors. I share my reflections on issues of intervention and research design, as well as how research results fostered my…

Objective: The current study reports functional outcomes from a multi-site randomized trial of a cognitive-behavioral treatment program for college students diagnosed with ADHD. Methods: A sample of emerging adults (N = 250; ages 18 to 30) currently attending college were comprehensively evaluated and diagnosed with ADHD (M age = 19.7; 66% female,…

Purpose: To investigate the efficiency of a single-session character-strength-based cognitive intervention on enhancing freshmen's adaptability. Method: A randomized trial, pretest, posttest, follow-up intervention was employed using repeated-measures analyses to evaluate the effect. This 90-min intervention contained four activities with 52…

The study is aimed at investigating the impact of orientation and mobility (O&M) training as a part of the special education curriculum on the social adjustment of visually impaired children. The population consisted of visually impaired children between the ages of (5-15), studying at different special education institutes in Pakistan was the…

Background and objectives: Although randomized controlled trials (RCTs) have been performed to alleviate loneliness among older people, little is known about how they have been implemented, or whether they are effective in real life. Our RCT-based model, "Circle of Friends" (CoF) proved to be effective in improving the wellbeing, health…

We assessed the impacts of a teacher professional development program for public and private kindergartens in the Greater Accra Region of Ghana. We examined impacts on teacher professional well-being, classroom quality, and children's readiness during one school year. This cluster-randomized trial included 240 schools (teachers N = 444; children N…

Background: This study investigated whether a personalized life story book and rummage box enhanced well-being and led to changes in behaviour for people with Down syndrome (DS) who have dementia. Materials and Methods: A randomized single case series design was used with five participants who had DS and a diagnosis of dementia. Participants were…