This study investigated caregivers' perspectives on applied behaviour analysis (ABA) intervention for children with autism spectrum disorder (ASD) in Ghana. Using a qualitative case study approach, data were collected from 13 teachers and six parents across two schools in the Central and Greater Accra Regions. Thematic analysis revealed seven major themes, including perspectives on communication, challenging behaviour, self-help skills, social skills, motor skills and attention. Findings suggest that ABA intervention yielded positive outcomes, with improvements noted in various skill areas. Children demonstrated increased independence in self-help tasks, reduced challenging behaviours and enhanced communication through alternative methods. Social and motor skills also improved, while attention showed gradual progress. Despite limitations such as a small sample size and lack of standardised measures, this study contributes valuable insights into ABA effectiveness in Ghana, potentially informing future research and policy decisions regarding ASD interventions in Sub-Saharan Africa.