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Issues Relating to Confounding and Meta-analysis When Including Non-Randomized Studies in Systematic Reviews on the Effects of Interventions
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Valentine, Jeffrey C.; Thompson, Simon G. – Research Synthesis Methods, 2013
Background: Confounding caused by selection bias is often a key difference between non-randomized studies (NRS) and randomized controlled trials (RCTs) of interventions. Key methodological issues: In this third paper of the series, we consider issues relating to the inclusion of NRS in systematic reviews on the effects of interventions. We discuss…
Descriptors: Research Design, Randomized Controlled Trials, Intervention, Bias