In the early 1980s, the "theory of didactic situations" put the analysis of mathematical activity at the core of the didactic analysis, thus initiating a new research programme in mathematics education: the "epistemological programme." This paper describes and interprets some of the contributions of the "anthropological theory of the didactic" (ATD) to the development of this programme. These contributions come from the new institutional and ecological perspective provided by the ATD to approach the didactic problem and from the significance it assigns to macrodidactic phenomena characterised by didactic transposition. They are illustrated with research works involving different fields of school mathematics in which the ATD team led by Spanish researchers played a central role: research in school algebra and its relations with functional modelling, differential calculus, and real numbers. The paper concludes by briefly describing the contributions of the ATD to the dialogue between didactic theories, another domain that has notable Spanish contributions.