The case study draws on design thinking. It offers a research and innovation case method to address so-called wicked problems, that is, complex problems with many interdependent and incomplete factors and variables requiring deep understanding of the involved stakeholders and the innovative approach provided by design thinking. The case takes as point of departure that inequalities are gendered and intersectional and aims to find solutions to reduce these complexities. It focuses on the use of Open Studios, a participatory method that uses design thinking to solve wicked problems in an inclusive and co-creative way, and is characterized by multistakeholder involvement. This case study includes concrete examples of how the Open Studios process was used to design social innovations as pilot actions that were implemented by civil society organizations representing marginalized groups as solutions in Europe. Open Studios are two-day co-creation workshops to develop innovative solutions to reduce gendered and intersectional inequalities. During the 2 days, the diverse participants go through a step-by-step process combining divergence (brainstorming) and convergence (solution development). The diversity of the participants and the techniques used lead to different operational outputs: ideas for social innovations, recommendations to policymakers (and other stakeholders), and the identification of knowledge gaps--all with the aim of reducing inequalities. This case study is based on the application of Open Studios in RESISTIRÉ, a European Union Horizon 2020 research and innovation project on the impact of COVID-19 policy responses on inequalities (2021-2023). The method described can be applied by all levels of research from postgraduate to professorial. [This content is provided in the format of an e-book.]