This article examines newly introduced eccentricity topological descriptors that are used to analyze the structures of polycyclic aromatic hydrocarbons. The purpose is to identify structural components that have a significant impact on physicochemical properties. Regression analysis applies to find potential correlation between different drugs…

Neuroinflammatory mechanisms have been implicated in the pathophysiology of autism spectrum disorder (ASD). Minocycline is a matrix metalloproteinase inhibitor 9 (MMP9) inhibitor tetracycline antibiotic with known anti-inflammatory properties. In preclinical animal models of ASD, minocycline has demonstrated potential positive effects on…

The subject of pharmaceutical research has traditionally focused on drugs with systemic effects. However, contemporary approaches aspire to achieve targeted drug delivery, with the aim of combatting infections with a precise immune response. Active substances are encapsulated in nanoparticles, transported through the body, and selectively released…

Medicinal chemistry is a core course for undergraduate students who major in pharmacy, where complex drug structures and abstruse concepts often pose significant challenges for students. As an important supplement to classroom teaching, online teaching resources have demonstrated the ability to enhance students' interest in learning and improve…

Since ancient times, man has prepared medicines and used them in healing practices. Therefore, there has always been a great interest in the part of people in general and students in particular about medicines. The "Medicines, the Haute Couture of Pharmacy" summer camp has the objective to promote and improve the literacy in medicines…

We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children's families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For…

A Drug Synthesis Reaction (DSR) course is required for undergraduates majoring in pharmacy, pharmaceutical engineering, and related majors. It aims to systematically teach students the theoretical knowledge and experimental skills of drug synthesis so that they can better adapt to drug synthesis related work after graduation. Given the…

One of the identified points of confusion and a barrier to students using generative artificial intelligence (GenAI) is knowing what their professor would consider appropriate use of GenAI in a classroom setting or course framework. This creates points of friction for instructors and students as they try to navigate an ever-changing landscape,…

This study aimed to explore stakeholders' perspectives on the ethical considerations for returning individual pharmacogenomics research results to people living with HIV. A qualitative approach to investigation involved five focus group discussions with 30 Community representatives, 12 key informant interviews with researchers, and 12 in-depth…

During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed populations, later trials are more likely to enroll biomarker-positive patients alone, thus leading to trials of the same treatment investigated in different populations. When…

Purpurogallin (PPG), an orange-red crystalline compound from nutgalls and oak bark, is an exemplar of numerous, ubiquitous natural colorants, biosynthesized through oxidative dimerization-decarboxylation of phenolic compounds. It possesses antioxidant, anticancer, and anti-inflammatory effects. Herein, a robust method is presented to allow…

Scientific literacy is a person's ability to think and behave scientifically, apply scientific knowledge, and make decisions in solving problems in everyday life. Biology students are expected to be able to develop scientific literacy. One of them is in the material of plant metabolism. Understanding the concept of plant metabolism will help…

A multicomponent reaction was adapted and successfully applied in the major organic course, which involves synthesizing and characterizing a 1,3-benzoxazine derived from paracetamol extracted from tablets of the worldwide well-known medicine Tylenol. Using paracetamol as a reagent is a motivational strategy in undergraduate laboratories to meet…

Microfluidics has attracted widespread interest in the fields of chemicals, materials, pharmaceuticals, biology, etc. Integrating low-cost automation based on open-source hardware/software to improve lab security and reduce time consumption is demanded in microchemical processing. In this work, we developed a "do it yourself"…

Heterocyclic compounds are an integral part of research, particularly in the pharmaceutical field. The synthesis of such compounds in an undergraduate laboratory can help students understand the relevance and importance of their field of study. Our experimental activity introduces a novel procedure to synthesize coumarin, a heterocyclic formed by…