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Hemodynamic and Electrophysiological Connectivity in the Language System: Simultaneous Near-Infrared Spectroscopy and Electrocorticography Recordings during Cortical Stimulation
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Sato, Yosuke; Oishi, Makoto; Fukuda, Masafumi; Fujii, Yukihiko – Brain and Language, 2012
We applied near-infrared spectroscopy (NIRS) and electrocorticography (ECoG) recordings during cortical stimulation to a temporal lobe epilepsy patient who underwent subdural electrode implantation. Using NIRS, changes in blood concentrations of oxyhemoglobin (HbO[subscript 2]) and deoxyhemoglobin (HbR) during cortical stimulation of the left…
Descriptors: Metabolism, Spectroscopy, Cognitive Processes, Brain Hemisphere Functions
Neuronal Networks in Children with Continuous Spikes and Waves during Slow Sleep
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Siniatchkin, Michael; Groening, Kristina; Moehring, Jan; Moeller, Friederike; Boor, Rainer; Brodbeck, Verena; Michel, Christoph M.; Rodionov, Roman; Lemieux, Louis; Stephani, Ulrich – Brain, 2010
Epileptic encephalopathy with continuous spikes and waves during slow sleep is an age-related disorder characterized by the presence of interictal epileptiform discharges during at least greater than 85% of sleep and cognitive deficits associated with this electroencephalography pattern. The pathophysiological mechanisms of continuous spikes and…
Descriptors: Patients, Brain Hemisphere Functions, Sleep, Epilepsy
The Structural Plasticity of White Matter Networks Following Anterior Temporal Lobe Resection
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Yogarajah, Mahinda; Focke, Niels K.; Bonelli, Silvia B.; Thompson, Pamela; Vollmar, Christian; McEvoy, Andrew W.; Alexander, Daniel C.; Symms, Mark R.; Koepp, Matthias J.; Duncan, John S. – Brain, 2010
Anterior temporal lobe resection is an effective treatment for refractory temporal lobe epilepsy. The structural consequences of such surgery in the white matter, and how these relate to language function after surgery remain unknown. We carried out a longitudinal study with diffusion tensor imaging in 26 left and 20 right temporal lobe epilepsy…
Descriptors: Epilepsy, Surgery, Patients, Brain Hemisphere Functions
Limitations to Plasticity of Language Network Reorganization in Localization Related Epilepsy
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Mbwana, J.; Berl, M. M.; Ritzl, E. K.; Rosenberger, L.; Mayo, J.; Weinstein, S.; Conry, J. A.; Pearl, P. L.; Shamim, S.; Moore, E. N.; Sato, S.; Vezina, L. G.; Theodore, W. H.; Gaillard, W. D. – Brain, 2009
Neural networks for processing language often are reorganized in patients with epilepsy. However, the extent and location of within and between hemisphere re-organization are not established. We studied 45 patients, all with a left hemisphere seizure focus (mean age 22.8, seizure onset 13.3), and 19 normal controls (mean age 24.8) with an fMRI…
Descriptors: Brain Hemisphere Functions, Epilepsy, Patients, Language Processing
The Neurologic Manifestations of Mitochondrial Disease
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Parikh, Sumit – Developmental Disabilities Research Reviews, 2010
The nervous system contains some of the body's most metabolically demanding cells that are highly dependent on ATP produced via mitochondrial oxidative phosphorylation. Thus, the neurological system is consistently involved in patients with mitochondrial disease. Symptoms differ depending on the part of the nervous system affected. Although almost…
Descriptors: Diseases, Patients, Anatomy, Genetic Disorders
Down Syndrome in the Neurology Clinic: Too Much? Too Little? Too Late?
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Larner, Andrew J. – Down Syndrome Research and Practice, 2007
This paper presents a review of all patients with Down syndrome seen over a 5-year period by one consultant neurologist in general outpatient and specialist cognitive function clinics. It revealed only 7 cases in greater than 4500 general referrals (= 0.2%), all referred with suspected seizure disorders. The diagnosis of epilepsy was confirmed in…
Descriptors: Mental Retardation, Seizures, Down Syndrome, Neurology