3D printers have facilitated a wealth of 3D printed molecular models illustrating key structural concepts for student learning. However, general adoption of 3D printed models in the organic chemistry classroom proceeds slowly as the majority of consumer-grade 3D (fused deposition modeling (FDM) and resin) printers are inherently monochromatic, limited to printing a single color at a time. Here, we report a general procedure for 3D printed multicolor space-filling molecular models and molecular orbital models using freely available software that can be printed and assembled using accessible and affordable consumer-grade 3D printers.