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Direct linkLiu, Rong-Yu; Neveu, Curtis; Smolen, Paul; Cleary, Leonard J.; Byrne, John H. – Learning & Memory, 2017
Developing treatment strategies to enhance memory is an important goal of neuroscience research. Activation of multiple biochemical signaling cascades, such as the protein kinase A (PKA) and extracellular signal-regulated kinase (ERK) pathways, is necessary to induce long-term synaptic facilitation (LTF), a correlate of long-term memory (LTM).…
Descriptors: Drug Therapy, Biochemistry, Pharmacology, Intervention
Kim, Seunghyun; Heo, Ryoun; Chung, Yeonji; Kim, Jung Min; Kwon, Michelle P.; Seo, Sung Chul; Park, Gil-Hong; Kim, Meyoung-Kon – Journal of Science Education and Technology, 2019
A major goal of education is to help students retain as much meaningful information as possible for long periods of time. The learning process by which students acquire new knowledge and behaviors is closely related to memory, which is the core of cognition. In a previous study, we developed virtual reality visualization model (VRVM) that can be…
Descriptors: Computer Simulation, Metabolism, Biochemistry, Learning Processes
Akkerman, Sven; Blokland, Arjan; Prickaerts, Jos – Learning & Memory, 2016
In previous studies, we have shown that acetylcholinesterase inhibitors and phosphodiesterase inhibitors (PDE-Is) are able to improve object memory by enhancing acquisition processes. On the other hand, only PDE-Is improve consolidation processes. Here we show that the cholinesterase inhibitor donepezil also improves memory performance when…
Descriptors: Drug Use, Biochemistry, Learning Processes, Memory
Chatham, Christopher H.; Herd, Seth A.; Brant, Angela M.; Hazy, Thomas E.; Miyake, Akira; O'Reilly, Randy; Friedman, Naomi P. – Journal of Cognitive Neuroscience, 2011
A paradigmatic test of executive control, the n-back task, is known to recruit a widely distributed parietal, frontal, and striatal "executive network," and is thought to require an equally wide array of executive functions. The mapping of functions onto substrates in such a complex task presents a significant challenge to any theoretical…
Descriptors: Short Term Memory, Cognitive Processes, Task Analysis, Brain Hemisphere Functions
Steward, Oswald; Huang, Fen; Guzowski, John F. – Learning & Memory, 2007
Stimulation paradigms that induce perforant path long-term potentiation (LTP) initiate phosphorylation of ERK1/2 and induce expression of a variety of immediate early genes (IEGs). These events are thought to be critical components of the mechanism for establishing the changes in synaptic efficacy that endure for hours or longer. Here we show that…
Descriptors: Stimulation, Seizures, Animals, Behavior Modification
Celerier, Aurelie; Pierard, Christophe; Rachbauer, Dagmar; Sarrieau, Alain; Beracochea, Daniel – Learning & Memory, 2004
The present study was aimed at simultaneously determining on the same subject, the effects of stress on retrieval of flexible (contextual or temporal) or stable (spatial) information. Three behavioral paradigms carried out in a four-hole board were designed as follows: (1) Simple Discrimination (SD), in which mice learned a single discrimination;…
Descriptors: Animals, Anxiety, Models, Discrimination Learning
