Relative quantification is a popular analysis in gene expression studies using quantitative real-time PCR (qPCR). However, the calculation steps using the major algorithms for this analysis are rather complicated. In this study, we developed an easy-to-use spreadsheet-based method for relative quantification. The inputs from end-users are the…

The need to benefit from information technologies in the twenty-first century digital age is increasing in all economies to overcome problems and difficulties and to have desired solutions. So, developing algorithmic thinking has been important as a skill that requires the application of knowledge from different disciplines, especially science,…

An educational team founded by Seymour Papert at MIT has developed an evolving series of computing environments designed to facilitate computational thinking. Papert outlined the goal of developing educational environments to facilitate the use of computer as a computational object in a seminal publication, "Teaching Children Thinking"…

Number sense is the foundation of arithmetic and algebra, yet relatively little research has deeply investigated what children do as they develop number sense. This case study provides insights into that development as it occurred during interactions with a multi-touch mathematics digital game, including conceptually congruent gestures. Findings…

Computational creativity, the generation of new, unimagined ideas or artifacts by a machine that are deemed creative by people, can be applied in the culinary domain to create novel and flavorful dishes. In fact, we have done so successfully using a combinatorial algorithm for recipe generation combined with statistical models for recipe ranking…

Automated grammar correction techniques have seen improvement over the years, but there is still much room for increased performance. Current correction techniques mainly focus on identifying and correcting a specific type of error, such as verb form misuse or preposition misuse, which restricts the corrections to a limited scope. We introduce a…

In the last decades there have been several attempts to use computers in Music Education. New pedagogical trends encourage incorporating technology tools in the process of learning music. Between them, those systems based on Artificial Intelligence are the most promising ones, as they can derive new information from the inputs and visualize them…

There are increasing calls to prepare K-12 students to use computational tools and principles when exploring scientific or mathematical phenomena. The purpose of this paper is to explore whether and how constructionist computer-supported collaborative environments can explicitly engage students in this practice. The Categorizer is a…

The concept of function is a central but difficult topic in secondary school mathematics curricula, which encompasses a transition from an operational to a structural view. The question in this paper is how the use of computer tools may foster this transition. With domain-specific pedagogical knowledge on the learning of function as a point of…

We introduce a new open source (free) software package that provides a simple, highly interactive interface for carrying out certain mathematical tasks that are commonly encountered in physics. These tasks include plotting and animating functions, solving systems of coupled algebraic equations, and basic calculus (differentiating and integrating…

A "Framework for K-12 Science Education" identified eight practices as "essential elements of the K-12 science and engineering curriculum" (NRC 2012, p. 49). Most of the practices, such as Developing and Using Models, Planning and Carrying Out Investigations, and Analyzing and Interpreting Data, are well known among science…

In the Western Gregorian Calendar, the date of Easter Sunday is defined as the Sunday following the ecclesiastical Full Moon that falls on or next after March 21. While the pattern of dates so defined usually repeats each 19 years, there is a 0.08 day difference between the cycles. More accurately, the system has a period of 70 499 183 lunations…

This paper introduces the language associated with a polygon microworld called Polygon R&D, which has the mathematical crispness of Logo and has the discreteness and simplicity of a Turing machine. In this microworld, polygons serve two purposes: as agents (similar to the turtles in Logo), and as data (landmarks in the plane). Programming the…

Three level-implicit finite difference methods of order four are discussed for the numerical solution of the mildly quasi-linear second-order hyperbolic equation A(x, t, u)u[subscript xx] + 2B(x, t, u)u[subscript xt] + C(x, t, u)u[subscript tt] = f(x, t, u, u[subscript x], u[subscript t]), 0 less than x less than 1, t greater than 0 subject to…

High-performance computers coupled with highly efficient numerical schemes and user-friendly software packages have helped instructors to teach numerical solutions and analysis of various nonlinear models more efficiently in the classroom. One of the main objectives of a model is to provide insight about the system of interest. Analytical…