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Download full textBerry, Donald A. – 1989
The use of a Bayesian approach in evaluating data from clinical trials with many treatment centers and from many studies is discussed. The main distinction between a metaanalysis and an analysis of a multicenter trial is that different studies may have very different designs, while the centers in a multicenter trial usually follow the same…
Descriptors: Bayesian Statistics, Drug Use, Mathematical Models, Meta Analysis
Berry, Donald A. – 1990
In clinical trials, adaptive allocation means that the therapies assigned to the next patient or patients depend on the results obtained thus far in the trial. Although many adaptive allocation procedures have been proposed for clinical trials, few have actually used adaptive assignment, largely because classical frequentist measures of inference…
Descriptors: Bayesian Statistics, Mathematical Models, Patients, Research Methodology
