There is considerable evidence that in rats, the insular cortex (IC) and amygdala are involved in the learning and memory of aversively motivated tasks. The present experiments examined the effects of 8-Br-cAMP, an analog of cAMP, and oxotremorine, a muscarinic agonist, infused into the IC after inhibitory avoidance (IA) training and during the…

Synapses formed by the olfactory nerve (ON) provide the source of excitatory synaptic input onto mitral cells (MC) in the olfactory bulb. These synapses, which relay odor-specific inputs, are confined to the distally tufted single primary dendrites of MCs, the first stage of central olfactory processing. Beta-adrenergic modulation of electrical…

The transcription factor cAMP response-element binding protein (CREB) has a pivotal role in hippocampal synaptic plasticity and hippocampus-dependent long-term memory. We recently demonstrated that the dorsal hippocampal CA3 region is involved in memory consolidation of spatial information tested on a Morris water maze in mice. To test whether…

Lesions of the basolateral amygdala (BLA) have long been associated with abnormalities of taste-related behaviors and with failure in a variety of taste- and odor-related learning paradigms, including taste-potentiated odor aversion, conditioned taste preference, and conditioned taste aversion. Still, the general role of the amygdala in…

The first gene-targeting studies that examined learning and memory in mice were performed in 1992 (Grant et al. 1992; Silva et al. 1992). The ultimate goal of this new field was to understand the molecular and cellular process underlying normal cognition and how they may be altered in disease states. In the years since these pioneering studies,…

Voltage-gated potassium channels (Kv) are critically involved in learning and memory processes. It is not known, however, whether the expression of the Kv1.1 subunit, constituting Kv1 channels, can be specifically regulated in brain areas important for learning and memory processing. Radioactive in situ hybridization was used to evaluate the…

These experiments attempt to optimize the possibility of demonstrating blocking in a taste-aversion paradigm and to elucidate the conditions under which this interference occurs. (Author/RK)

To complement investigations of the direct effects of lithium toxicosis on consummatory behavior, these experiments were designed to determine the aftereffects on drinking of exposure to a conditioned stimulus previously paired with lithium. (Author/RK)

In four different experiments, brief illumination of a localized visual stimulus was followed by grain presentation unless the pigeon approached the light. Results indicate that although response-reinforcer relations do play a role, stimulus-reinforcer contingencies are the dominant factor in establishing and maintaining approaches to the…

Rats were trained to search for a food reward hidden under sawdust in the center of a square-shaped enclosure designed to force orientation on the basis of the overall geometry of the environment. They were then tested in a number of enclosures differing in shape and in size (rectangular-, double-side square-, and equilateral triangle-shaped…

An analysis of two paradigms suggests that predictions in regard to the effects of stimulus preexposure must take into account not only the novelty of the stimulus, but the relationship of that novelty to that of the environment at the time of testing. (Editor/RK)

Analyzes the temporal features of the transient unconditioned stimulus preexposure effect observed by Cannon (EJ 123 672) and attempts to determine whether a preconditioned stimulus toxin presentation can both condition a backward taste aversion and interfere with the development of a forward aversion. (Author/RK)

Comments on Gauvain's discussion, in this issue, of the development of thinking from a sociocultural perspective, expanding her analysis by comparing research on apes who have developed in natural habitats with apes raised by humans in something resembling a human culture. Argues that the study of nonhuman primates can contribute to the emerging…