An operationally straightforward, project-like laboratory experiment has been developed in which students directly compare the reactivity of two heterocycles, a cyclic "O,O"-acetal (standard C-O protecting group) and a cyclic "N,O"-acetal (oxazolidine), toward sodium borohydride and methylmagnesium iodide. Students synthesize a…

Water exhibits a maximum in density at normal pressure at around 4° degree temperature. This paper demonstrates that during cooling, at around 4 °C, the temperature remains constant for a while because of heat exchange associated with convective currents inside the water. Superficial approach implies it as a new anomaly of water, but actually it…

One dimensional (1-D)[superscript 1] H and [superscript 13]C NMR experiments are common tools used in undergraduate organic laboratories to characterize synthesized molecules. However, 1-D NMR spectra cannot always provide unambiguous structure determination. In research laboratories, advanced NMR spectroscopy methods are employed for structural…

The development of an enzyme-mediated reaction for the first-year general, organic, and biological chemistry (GOB) teaching laboratory is of significant importance so that the factors that affect enzyme-mediated reactions can be adequately demonstrated, reinforcing the lecture portion of the GOB course. Some of the factors that affect these types…

This laboratory experiment introduces the fundamentals of electrochemical techniques to the undergraduate students by developing a simple and cost-effective miniaturized electrochemical setup for detecting UV-induced DNA damage. This is an imperative experiment, as it provides students first-hand experience with electrochemical techniques while…

Mass spectrometers are ever-increasingly powerful, user-friendly, and affordable. Thus, the addition of mass spectrometry experiments into the undergraduate laboratory curriculum is now both feasible and an effective tool to introduce students to relevant instrumentation. Here an experiment demonstrating the use of a high-resolution electrospray…

Experiments written for students who were quarantined during the COVID-19 pandemic are described. These were developed to provide hands-on lab experiences that students would not get due to the online nature of course offerings during the crisis. The laboratories described include an extraction and oxidation of aldehydes from food items, a study…

Given student familiarity with electronic cigarettes (e-cigs), this lab uses a student-built smoke collection apparatus to collect e-cig vapors to teach students about gas chromatography-mass spectrometry (GC-MS). Students in a second semester, introductory organic chemistry course spent 1 week collecting e-cig vapors and 1 week qualitatively…

Demonstration of a colorimetric approach for nucleic acid detection represents an attractive educational experiment for chemistry undergraduate students in the time of coronavirus pandemic. Herein, a rapid and vivid detection method that visualizes the presence of a specific DNA sequence is described. The plasmon resonance of gold nanoparticles…

A two-week summer camp was designed, implemented, and then updated for high school students focusing on organic chemistry, solar energy, and green chemistry principles. Students learn about laboratory safety, perform organic reactions, go on field trips, and take part in interactive lessons that focus on both fundamental chemistry topics as well…

In this article, we present a low-cost lab experience, enhanced by new technologies and easy to execute. The objective of the experiment is to explore the moment of inertia of a fidget spinner quantitatively. Our choice was to integrate the teaching of physics with the use of a popular toy, the fidget spinner, very popular among young people and…

Teaching emulsion polymerization is an important benchmark in undergraduate polymer courses. However, the introduction of hands-on experiments in undergraduate polymer laboratories is challenging: experimental time, reagents, and equipment involved are the primary restraints. We report a practical emulsion polymerization laboratory experiment for…

A multifaceted experiment, accessible to students either in an introductory organic chemistry course or in a more advanced laboratory setting, is described for investigating the addition of dichlorocarbene to E- and Z-[beta]-methylstyrenes. The innovative exercise, which integrates elements of synthesis, mechanisms, instrumental analysis,…

An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC-MS and NMR spectroscopy. This protocol is suitable for…

The stated purpose of this paper is to provide a simple and quick method to assemble pH electrodes using readily available materials. The present assembled electrodes are comparable with commercial pH electrodes, with accuracy for pH determination in the range 2-12. Furthermore, the constructed simple pH electrodes exhibit a fast and stable…