The subject of pharmaceutical research has traditionally focused on drugs with systemic effects. However, contemporary approaches aspire to achieve targeted drug delivery, with the aim of combatting infections with a precise immune response. Active substances are encapsulated in nanoparticles, transported through the body, and selectively released…

Only limited experimental designs for the synthesis of heterocyclic compounds are provided in current widely used Organic Chemistry Experiment textbooks, which cannot meet the practical needs of teaching. Under the concept of green chemistry, this study provides an innovative protocol for the synthesis of a thiazoline heterocycle from…

A major challenge when designing new experiments for the general chemistry laboratory is introducing students to the necessary techniques while keeping the experiment engaging and accessible. This work presents a new multiweek activity designed to introduce students to advanced instrumentation in the form of high-performance liquid chromatography…

After a time away from the classrooms and laboratories due to the global pandemic, the return to teaching activities during the semester represented a challenge to both teachers and students. Our particular situation in a Microbial Physiology course was the necessity of imparting in shorter time, laboratory practices that usually take longer. This…

Ferrocene is an organometallic compound widely incorporated into undergraduate organic and inorganic chemistry curricula. Traditional laboratory experiments typically involve the Friedel-Crafts acylation of ferrocene to produce acetylferrocene or diacetylferrocene, with a purification method focused on column chromatography. To expand the…

Photochemical reactions are initiated by the absorption of light, triggering the chemical reactions and resulting in the formation of products. These reactions are generally performed using a freely available renewable source of energy-solar energy. Solar simulators mimic both the ultraviolet and visible regions of sunlight and hence can serve as…

Here, a relatively simple laboratory experiment of a physical pendulum, suitable for students of science and engineering in the first courses of university physics, is presented to illustrate its dynamic behavior and to determine its inertia moment. To this end, a long wooden rod of length L = 99.8 cm and cross-section radius R = 1.73 cm was used…

While elimination reactions are ubiquitous in organic chemistry textbooks, their implementation in undergraduate laboratories still suffers from a lack of reliable and easy setup procedures. This paper describes an easy-to-implement set of elimination experiments in the pentanol and bromopentane series using a modified Hickman distillation head.…

In this laboratory experiment, a guided inquiry exploring the physicochemical principles of the dissolution of Ca(OH)[subscript 2](s) in water is proposed for laboratory classes in university and high school. As part of students' inquiry, two experimental approaches are used. One is the change in solubility with temperature revealed by measuring…

This study reports an undergraduate laboratory experiment that explores the temperature-dependent kinetics of caffeine release during tea steeping by using quantitative [superscript 1]H NMR spectroscopy with a water suppression pulse sequence. Designed for introductory organic chemistry laboratory courses, the experiment emphasizes the real-world…

Starting with a double replacement reaction in alcohol between Ni(H[subscript 2]O)[subscript 6](NO[subscript 3])[subscript 2] and NaX, students exploit solubility differences to produce a solution of NiX[subscript 2] and a NaNO[subscript 3] precipitate. They then synthesize a bis(N,N-diethylethylenediamine) Ni(II) complex with chloride, bromide,…

Instruction in quantum mechanics is becoming increasingly important as the field is not only a key part of modern physics research but is also important for emerging technologies. However, many students regard quantum mechanics as a particularly challenging subject, in part because it is considered very mathematical and abstract. One potential way…

The Ouchterlony double immunodiffusion technique is used as a teaching tool for studying immune responses and exemplifying differences in antigen-antibody reactions. Although commonplace in undergraduate labs, standardized commercial kits limit learning experiences because they have fixed modalities of use, a low shelf-life, and impose budgetary…

S[subscript N]2 reactions are of fundamental importance in introductory organic chemistry courses, and a number of experiments suitable for the first-semester undergraduate organic lab have been previously reported. Most of these experiments have used alkyl halides as electrophiles, but alkyl halides are often less than ideal for reasons of…

A [beta]-lactam, the core structure unit of clinically important antibiotics such as penicillin and cephalosporin, is one of the most commonly encountered four-membered heterocycles in organic chemistry and is widely used in medicine and biochemistry. The Kinugasa reaction, a copper­(I)-catalyzed cycloaddition of a terminal alkyne with a nitrone,…