We created a novel laboratory experience where undergraduate students explore the techniques used to study protein misfolding, unfolding, and aggregation. Despite the importance of protein misfolding and aggregation diseases, protein unfolding is not typically explored in undergraduate biochemistry laboratory classes. Yeast alcohol dehydrogenase…

The so-called Diet Coke and Mentos experiment is initiated by dropping Mentos candies into a bottle of Diet Coke or other carbonated beverage. This causes the beverage to rapidly degas, causing foam to stream out of the bottle. Simple application of the gas laws leads to the straightforward prediction that ejection of greater foam volume is…

A novel method of measuring the coefficients of kinetic and rolling friction is proposed. The method is simple to implement and reliable. Samples of measurements and calculations are presented.

The cannon boring experiment of Count Rumford, where eight kilograms of water were boiled by metal on metal friction, is investigated. Consideration of this dramatic demonstration can enrich classroom discussions of calorimetry, units of measure, elements, and thermodynamics. A section pertaining to use of the article in the classroom appears…

The synthesis of N-methoxycarbonyl-2-imidazolidone, an analogue of biotin, was conducted by organic chemistry students and confirmed using FT-IR and H NMR. Spectroscopy students used FT-IR to measure the rate of hydrolysis of the product and determined the rate constant for the reaction using the integrated rate law. From the magnitude of the rate…

We have recently designed a biochemistry laboratory experiment for the purpose of providing students an advanced experience with enzyme kinetics and the kinetics of binding. Bestatin, a well-known and commercially available general protease inhibitor, is a slow-binding inhibitor of aminopeptidase isolated from "Aeromonas proteolytica." The binding…

Portable air purifiers are popular consumer items, especially in areas with poor air quality. Unfortunately, most users of these air purifiers have minimal understanding of the factors affecting their efficiency in typical indoor settings. Emission of the air pollutant ozone (O[subscript 3]) by certain air purifiers is of particular concern. In an…

The mercury-drag effect is demonstrated when mercury vapor diffuses through nitrogen gas at low pressure, passing through tubes of different radii to liquid nitrogen-cooled cold traps. The pressure changes of the nitrogen gas on the mercury-deficient side of the cold traps are observed and compared with theoretical and experimental valves from the…