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Suárez Casanova, Víctor Manuel; Shumskaya, Maria – Biochemistry and Molecular Biology Education, 2021
DNA structure has been leveraged in a variety of facets that allow scientists to perform a range of assays, including ones for identification of species, establishing evolutionary relationships between taxa, or even identifying individuals. Here, we present a DNA barcoding method as practical, hands-on approach that connects several experimental…
Descriptors: Genetics, Biochemistry, Science Instruction, Molecular Biology
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Punnoose, Jibin Abraham; Halvorsen, Ken; Chandrasekaran, Arun Richard – Journal of Chemical Education, 2020
There is a disconnect between the cutting-edge research done in academic laboratories, such as nanotechnology, and what is taught in undergraduate laboratories. In the current undergraduate curriculum, very few students get a chance to do hands-on experiments in nanotechnology-related fields, most of which are through selective undergraduate…
Descriptors: Undergraduate Students, Science Instruction, Genetics, Teaching Methods
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Krzysiak, Amanda; Doyle, Caroline; Huff, Mary O. – Biochemistry and Molecular Biology Education, 2022
Project-based (research-driven) laboratory courses stimulate student involvement, improve critical thinking and initiate cooperative learning. To this end, a 7-week laboratory project was designed for a sophomore cell biology course to reinforce the fundamental relationship between genotype and phenotype using yeast alcohol dehydrogenase I (ADH1).…
Descriptors: Genetics, Biochemistry, Student Projects, Laboratory Experiments
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Shen, Jie; Zhu, Xiang; Jin, Kai; Li, Ya; Gu, YiTian; Huang, Jiahong; Qu, Yulan; Li, Xiaoyu – Biochemistry and Molecular Biology Education, 2018
The development and evaluation of a 6-hours laboratory class, based on capillary electrophoresis (CE) and the detection of microbial contaminants, is described. It can be easily scaled up or down, to suit class sizes up to 188 and completed in a shorter time scale. CE uses narrow-bore fused-silica capillaries to separate a complex array of large…
Descriptors: Science Laboratories, Science Instruction, Molecular Structure, Genetics
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Jie Xu; Zhihua Shao; Song Jia; Jihong Sha; Jiao Li; Furong Gao; Xiujuan Shi; Juan Wang; Caixia Jin; Mei Jiang; Haibin Tian; Jinfeng Cao; Hu Pu; Lei Xu; Lixia Lu – Biochemistry and Molecular Biology Education, 2024
The laboratory practice "Primary culture and directional differentiation of rat bone marrow mesenchymal stem cells (BMSCs)" is part of a required course for sophomore medical students at Tongji university, which has been conducted since 2012. Blended learning has been widely applied in medical courses. Based on a student-centered…
Descriptors: Cytology, Biochemistry, Science Instruction, Laboratory Experiments
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Yeo, Brandon Pei Hui; Foong, Lian Chee; Tam, Sheh May; Lee, Vivian; Hwang, Siaw San – Biochemistry and Molecular Biology Education, 2018
Structures and functions of protein motifs are widely included in many biology-based course syllabi. However, little emphasis is placed to link this knowledge to applications in biotechnology to enhance the learning experience. Here, the conserved motifs of nucleotide binding site-leucine rich repeats (NBS-LRR) proteins, successfully used for the…
Descriptors: Genetics, Science Instruction, Teaching Methods, Biochemistry
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Lipchock, James M.; Ginther, Patrick S.; Douglas, Bonnie B.; Bird, Kelly E.; Loria, J. Patrick – Biochemistry and Molecular Biology Education, 2017
Here, we present a 10-week project-oriented laboratory module designed to provide a course-based undergraduate research experience in biochemistry that emphasizes the importance of biomolecular structure and dynamics in enzyme function. This module explores the impact of mutagenesis on an important active site loop for a biomedically-relevant…
Descriptors: Biochemistry, Undergraduate Students, Student Research, Genetics
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Sun, Ji-Zheng; Tang, Yu-Jing; Sa, Rong-Bo; Gao, Yan-Xia – Journal of Chemical Education, 2019
A bioinformatics laboratory experiment was designed to help undergraduate students learn RNA structure and function in biochemistry courses. In this laboratory experiment, students used 5S rRNAs as material to predict secondary structure and visualize three-dimensional (3D) structure. Students first downloaded molecular information from the 5S…
Descriptors: Science Laboratories, Laboratory Experiments, Science Experiments, Information Science
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Militello, Kevin T.; Lazatin, Justine C. – Biochemistry and Molecular Biology Education, 2017
Clustered regularly interspaced short palindromic repeats (CRISPRs) represent a novel type of adaptive immune system found in eubacteria and archaebacteria. CRISPRs have recently generated a lot of attention due to their unique ability to catalog foreign nucleic acids, their ability to destroy foreign nucleic acids in a mechanism that shares some…
Descriptors: Undergraduate Students, Biochemistry, Molecular Biology, Science Laboratories
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Kholod, Yana; Hoag, Erin; Muratore, Katlynn; Kosenkov, Dmytro – Journal of Chemical Education, 2018
The reported project-based laboratory unit introduces upper-division undergraduate students to the basics of computer-aided drug discovery as a part of a computational chemistry laboratory course. The students learn to perform model binding of organic molecules (ligands) to the DNA minor groove with computer-aided drug discovery (CADD) tools. The…
Descriptors: Science Laboratories, College Science, Undergraduate Study, Chemistry
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Ochoa, Stacy D.; Dores, Michael R.; Allen, John M.; Tran, Tuan; Osman, Maryan; Vázquez Castellanos, Nidia P.; Trejo, JoAnn; Zayas, Ricardo M. – Biochemistry and Molecular Biology Education, 2019
Undergraduate research experiences are excellent opportunities to engage students in science alongside experienced scientists, but at large institutions, it is challenging to accommodate all students. To address and engage a larger number of students, we developed a modular laboratory course based on the course-based undergraduate research…
Descriptors: Laboratory Experiments, Science Instruction, Undergraduate Students, Course Descriptions
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Kirby, Cait S.; Kolber, Natalie; Salih Almohaidi, Asmaa M.; Bierwert, Lou Ann; Saunders, Lori; Williams, Steven; Merritt, Robert – Biochemistry and Molecular Biology Education, 2016
An inversion polymorphism of the filamin and emerin genes at the tip of the long arm of the human X-chromosome serves as the basis of an investigative laboratory in which students learn something new about their own genomes. Long, nearly identical inverted repeats flanking the filamin and emerin genes illustrate how repetitive elements can lead to…
Descriptors: Genetics, Molecular Biology, Molecular Structure, College Science
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Witherow, D. Scott – Biochemistry and Molecular Biology Education, 2016
This work describes a 10-week laboratory project studying wild-type and mutant bacterial alkaline phosphatase, in which students purify, quantitate, and perform kinetic assays on wild-type and selected mutants of the enzyme. Students also perform plasmid DNA purification, digestion, and gel analysis. In addition to simply learning important…
Descriptors: Biochemistry, Laboratory Training, Microbiology, Genetics
Joseph M. Hayes – Journal of Chemical Education, 2014
A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target-drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid…
Descriptors: Visualization, Models, Visual Aids, Undergraduate Students
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Hubler, Tina; Adams, Patti; Scammell, Jonathan – American Biology Teacher, 2015
The molecular basis of evolution is an important and challenging concept for students to understand. In a previous article, we provided some of the scientific background necessary to teach this topic. This article features a series of laboratory activities demonstrating that molecular events can alter the genomes of organisms. These activities are…
Descriptors: Laboratory Experiments, Science Activities, Molecular Biology, Genetics
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