Cyberinfrastructure (CI) is a term that usually appears in scientific research, but rarely to be noticed as a scientific education tool. In this paper, I describe a transformative Cyberinfrastructure-based strategy to improve Science, Technology, Engineering and Mathematics (STEM) education at one of the historically black colleges. This strategy is built on two arms (i) infusing CI in STEM introductory courses and (ii) building a community of practice around CI among STEM faculty and students. The paper presents the framework of applying computational thinking elements as a pathway to use CI in education, and tactics put to create CI-based community of practice. Presented plan will be helpful for other to use computational thinking elements and CI resources for STEM disciplines.