Purpose: Digitization is reshaping the functioning of educational institutions. Large attention has been paid to the innovative service models enabled by digitization. However, the implications of digitization on employees' well-being need further investigation. The purpose of this paper is to examine the effects of digitization on psycho-social risks at work in a large sample of European educational institutions. Design/methodology/approach: Secondary data were collected from the third wave of the European Survey of Enterprises on New and Emerging Risks (ESENER). A serial mediation model was designed to obtain evidence on the implications of digitization on the psycho-social risks at work in 3,540 educational institutions. Alongside the direct implications of digitization on psycho-social risks, its indirect effects mediated by occupational health interventions and healthy workplace initiatives were investigated. Findings: Digitization exacerbated psycho-social stressors at work. Increasing time pressures and intensifying work, digitization imperiled the employees' well-being. Occupational health partially mediated the implications of digitization on psycho-social risks. Although healthy workplace interventions seemed to prevent the side effects of digitization on psycho-social risk, its mediating role was not statistically significant. Practical implications: Digitization should be accompanied by interventions aimed at ensuring occupational health and at promoting a healthy workplace to minimize its drawbacks on psycho-social risks. Occupational health creates a greater awareness of the negative effects of digitization on work-related stressors. Healthy workplace initiatives contribute to enhancing the employees' psycho-physical well-being. Originality/value: This study reports the negative implications of digitization on psycho-social risks at work in educational institutions, envisioning some avenues for further development.