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Direct linkMartin, Kiley; Musaus, Madeline; Navabpour, Shaghayegh; Gustin, Aspen; Ray, W. Keith; Helm, Richard F.; Jarome, Timothy J. – Learning & Memory, 2021
Strong evidence supports a role for protein degradation in fear memory formation. However, these data have been largely done in only male animals. Here, we found that following contextual fear conditioning, females, but not males, had increased levels of proteasome activity and K48 polyubiquitin protein targeting in the dorsal hippocampus, the…
Descriptors: Fear, Memory, Gender Differences, Animals
Sathiyakumar, Sankirthana; Carrasco, Sofia Skromne; Saad, Lydia; Richards, Blake A. – Learning & Memory, 2020
Behavioral flexibility is important in a changing environment. Previous research suggests that systems consolidation, a long-term poststorage process that alters memory traces, may reduce behavioral flexibility. However, exactly how systems consolidation affects flexibility is unknown. Here, we tested how systems consolidation affects: (1)…
Descriptors: Memory, Animals, Rewards, Food
Nartey, Michaelina N.; Peña-Castillo, Lourdes; LeGrow, Megan; Doré, Jules; Bhattacharya, Sriya; Darby-King, Andrea; Carew, Samantha J.; Yuan, Qi; Harley, Carolyn W.; McLean, John H. – Learning & Memory, 2020
In the olfactory bulb, a cAMP/PKA/CREB-dependent form of learning occurs in the first week of life that provides a unique mammalian model for defining the epigenetic role of this evolutionarily ancient plasticity cascade. Odor preference learning in the week-old rat pup is rapidly induced by a 10-min pairing of odor and stroking. Memory is…
Descriptors: Animals, Genetics, Learning, Olfactory Perception
Robinson, Holly; Pozzo-Miller, Lucas – Learning & Memory, 2019
Gene transcription is a crucial step in the sequence of molecular, synaptic, cellular, and systems mechanisms underlying learning and memory. Here, we review the experimental evidence demonstrating that alterations in the levels and functionality of the methylated DNA-binding transcriptional regulator MeCP2 are implicated in the learning and…
Descriptors: Genetics, Learning, Memory, Animals
Alexandrescu, Anamaria; Carew, Thomas J. – Learning & Memory, 2020
The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of "Aplysia" cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term…
Descriptors: Brain Hemisphere Functions, Memory, Spatial Ability, Sensory Integration
Duke, Corey G.; Kennedy, Andrew J.; Gavin, Cristin F.; Day, Jeremy J.; Sweatt, J. David – Learning & Memory, 2017
Using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated DNA methylation changes in CA1 hippocampus of Sprague-Dawley rats specific to threat learning at genes involved in synaptic transmission. Experience-dependent alternations in gene expression and DNA methylation were observed as early as 1 h…
Descriptors: Genetics, Animals, Memory, Brain
Yang, Qizong; Antonov, Igor; Castillejos, David; Nagaraj, Anagha; Bostwick, Caleb; Kohn, Andrea; Moroz, Leonid; Hawkins, Robert D. – Learning & Memory, 2018
Long-term but not short-term memory and synaptic plasticity in many brain areas require neurotrophin signaling, transcription, and epigenetic mechanisms including DNA methylation. However, it has been difficult to relate these cellular mechanisms directly to behavior because of the immense complexity of the mammalian brain. To address that…
Descriptors: Memory, Animals, Genetics, Brain
Sekeres, Melanie J.; Moscovitch, Morris; Grady, Cheryl L.; Sullens, D. Gregory; Winocur, Gordon – Learning & Memory, 2020
Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a…
Descriptors: Memory, Animals, Brain Hemisphere Functions, Conditioning
Jones, Meghan E.; Sillivan, Stephanie E.; Jamieson, Sarah; Rumbaugh, Gavin; Miller, Courtney A. – Learning & Memory, 2019
microRNAs (miRNAs) have emerged as potent regulators of learning, recent memory, and extinction. However, our understanding of miRNAs directly involved in regulating complex psychiatric conditions perpetuated by aberrant memory, such as in posttraumatic stress disorder (PTSD), remains limited. To begin to address the role of miRNAs in persistent…
Descriptors: Genetics, Stress Variables, Fear, Memory
Kutlu, Munir G.; Tumolo, Jessica M.; Holliday, Erica; Garrett, Brendan; Gould, Thomas J. – Learning & Memory, 2016
Exposure therapy, which focuses on extinguishing fear-triggering cues and contexts, is widely used to treat post-traumatic stress disorder (PTSD). Yet, PTSD patients who received successful exposure therapy are vulnerable to relapse of fear response after a period of time, a phenomenon known as spontaneous recovery (SR). Increasing evidence…
Descriptors: Fear, Cues, Animal Behavior, Animals
Aten, Sydney; Hansen, Katelin F.; Snider, Kaitlin; Wheaton, Kelin; Kalidindi, Anisha; Garcia, Ashley; Alzate-Correa, Diego; Hoyt, Kari R.; Obrietan, Karl – Learning & Memory, 2018
The microRNA miR-132 serves as a key regulator of a wide range of plasticity-associated processes in the central nervous system. Interestingly, miR-132 expression has also been shown to be under the control of the circadian timing system. This finding, coupled with work showing that miR-132 is expressed in the hippocampus, where it influences…
Descriptors: Neurology, Brain Hemisphere Functions, Memory, Animals
Ciernia, Annie Vogel; Kramár, Enikö A.; Matheos, Dina P.; Havekes, Robbert; Hemstedt, Thekla J.; Magnan, Christophe N.; Sakata, Keith; Tran, Ashley; Azzawi, Soraya; Lopez, Alberto; Dang, Richard; Wang, Weisheng; Trieu, Brian; Tong, Joyce; Barrett, Ruth M.; Post, Rebecca J.; Baldi, Pierre; Abel, Ted; Lynch, Gary; Wood, Marcelo A. – Learning & Memory, 2017
Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it remains unclear how mutations in BAF complexes result in impaired cognitive function. Post-mitotic…
Descriptors: Intellectual Disability, Autism, Genetics, Neurological Impairments
Dynamic Expression of FKBP5 in the Medial Prefrontal Cortex Regulates Resiliency to Conditioned Fear
Criado-Marrero, Marangelie; Morales Silva, Roberto J.; Velazquez, Bethzaly; Hernández, Anixa; Colon, María; Cruz, Emmanuel; Soler-Cedeño, Omar; Porter, James T. – Learning & Memory, 2017
The factors influencing resiliency to the development of post-traumatic stress disorder (PTSD) remain to be elucidated. Clinical studies associate PTSD with polymorphisms of the FK506 binding protein 5 (FKBP5). However, it is unclear whether changes in FKBP5 expression alone could produce resiliency or susceptibility to PTSD-like symptoms. In this…
Descriptors: Brain, Conditioning, Fear, Posttraumatic Stress Disorder
Yu, Dinghui; Tan, Ying; Chakraborty, Molee; Tomchik, Seth; Davis, Ronald L. – Learning & Memory, 2018
The evolutionarily conserved Elongator Complex associates with RNA polymerase II for transcriptional elongation. Elp3 is the catalytic subunit, contains histone acetyltransferase activity, and is associated with neurodegeneration in humans. Elp1 is a scaffolding subunit and when mutated causes familial dysautonomia. Here, we show that…
Descriptors: Olfactory Perception, Animals, Genetics, Memory
Tamvacakis, Arianna N.; Senatore, Adriano; Katz, Paul S. – Learning & Memory, 2015
The sea slug "Hermissenda crassicornis" (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the "Hermissenda" brain transcriptome was sequenced and assembled de novo, producing 165,743…
Descriptors: Animals, Genetics, Learning, Memory
