Publication Date
| In 2026 | 0 |
| Since 2025 | 0 |
| Since 2022 (last 5 years) | 1 |
| Since 2017 (last 10 years) | 11 |
| Since 2007 (last 20 years) | 47 |
Descriptor
| Brain | 72 |
| Genetics | 72 |
| Animals | 71 |
| Memory | 23 |
| Neurological Organization | 19 |
| Brain Hemisphere Functions | 15 |
| Conditioning | 14 |
| Fear | 14 |
| Neurological Impairments | 14 |
| Animal Behavior | 13 |
| Biochemistry | 13 |
| More ▼ | |
Source
Author
| Abel, Ted | 4 |
| Sweatt, J. David | 4 |
| Kandel, Eric R. | 3 |
| Bourtchouladze, Rusiko | 2 |
| Hoeffer, Charles A. | 2 |
| Kenney, Justin W. | 2 |
| Klann, Eric | 2 |
| Levenson, Jonathan M. | 2 |
| Richter, Joel D. | 2 |
| Rosenblum, Kobi | 2 |
| Wood, Marcelo A. | 2 |
| More ▼ | |
Publication Type
| Journal Articles | 68 |
| Reports - Research | 49 |
| Reports - Descriptive | 12 |
| Reports - Evaluative | 8 |
| Books | 2 |
| Collected Works - General | 2 |
| Information Analyses | 1 |
| Reference Materials -… | 1 |
Education Level
| Higher Education | 3 |
| Elementary Secondary Education | 2 |
| High Schools | 1 |
| Postsecondary Education | 1 |
| Secondary Education | 1 |
Audience
| Teachers | 1 |
Location
| Germany | 1 |
| Netherlands | 1 |
| Spain | 1 |
Laws, Policies, & Programs
Assessments and Surveys
What Works Clearinghouse Rating
Peer reviewed
Direct linkFry, Benjamin R.; Pence, Nathan T.; McLocklin, Andrew; Johnson, Alexander W. – Learning & Memory, 2021
The dopamine system has been implicated in decision-making particularly when associated with effortful behavior. We examined acute optogenetic stimulation of dopamine cells in the ventral tegmental area (VTA) as mice engaged in an effort-based decision-making task. Tyrosine hydroxylase-Cre mice were injected with Cre-dependent ChR2 or eYFP control…
Descriptors: Decision Making, Brain, Cognitive Processes, Stimulation
Deirdre M. McCarthy; Thomas J. Spencer; Pradeep G. Bhide – Journal of Attention Disorders, 2024
Objective: We offer an overview of ADHD research using mouse models of nicotine exposure. Method: Nicotine exposure of C57BL/6 or Swiss Webster mice occurred during prenatal period only or during the prenatal and the preweaning periods. Behavioral, neuroanatomical and neurotransmitter assays were used to investigate neurobiological mechanisms of…
Descriptors: Models, Attention Deficit Hyperactivity Disorder, Smoking, Animals
Duke, Corey G.; Kennedy, Andrew J.; Gavin, Cristin F.; Day, Jeremy J.; Sweatt, J. David – Learning & Memory, 2017
Using a hippocampus-dependent contextual threat learning and memory task, we report widespread, coordinated DNA methylation changes in CA1 hippocampus of Sprague-Dawley rats specific to threat learning at genes involved in synaptic transmission. Experience-dependent alternations in gene expression and DNA methylation were observed as early as 1 h…
Descriptors: Genetics, Animals, Memory, Brain
Heuer, Sarah E.; Neuner, Sarah M.; Hadad, Niran; O'Connell, Kristen M. S.; Williams, Robert W.; Philip, Vivek M.; Gaiteri, Chris; Kaczorowski, Catherine C. – Learning & Memory, 2020
Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and behavioral data from a mouse population designed to model human variation in cognitive outcomes to…
Descriptors: Cognitive Processes, Resilience (Psychology), Alzheimers Disease, Genetics
Yang, Qizong; Antonov, Igor; Castillejos, David; Nagaraj, Anagha; Bostwick, Caleb; Kohn, Andrea; Moroz, Leonid; Hawkins, Robert D. – Learning & Memory, 2018
Long-term but not short-term memory and synaptic plasticity in many brain areas require neurotrophin signaling, transcription, and epigenetic mechanisms including DNA methylation. However, it has been difficult to relate these cellular mechanisms directly to behavior because of the immense complexity of the mammalian brain. To address that…
Descriptors: Memory, Animals, Genetics, Brain
Iacoangeli, Anna; Dosunmu, Aderemi; Eom, Taesun; Stefanov, Dimitre G.; Tiedge, Henri – Learning & Memory, 2017
Dendritic regulatory BC1 RNA is a non-protein-coding (npc) RNA that operates in the translational control of gene expression. The absence of BC1 RNA in BC1 knockout (KO) animals causes translational dysregulation that entails neuronal phenotypic alterations including prolonged epileptiform discharges, audiogenic seizure activity in vivo, and…
Descriptors: Genetics, Animals, Brain Hemisphere Functions, Brain
Zhang, Wen-Hua; Zhou, Jin; Pan, Han-Qing; Wang, Xiao-Yang; Liu, Wei-Zhu; Zhang, Jun-Yu; Yin, Xiao-Ping; Pan, Bing-Xing – Learning & Memory, 2017
The role of d subunit-containing GABA[subscript A] receptor (GABA[subscript A](d)R) in fear generalization is uncertain. Here, by using mice with or without genetic deletion of GABA[subscript A](d)R and using protocols in which the conditioned tone stimuli were cross presented with different nonconditioned stimuli, we observed that when the two…
Descriptors: Adults, Animals, Fear, Brain
Ciernia, Annie Vogel; Kramár, Enikö A.; Matheos, Dina P.; Havekes, Robbert; Hemstedt, Thekla J.; Magnan, Christophe N.; Sakata, Keith; Tran, Ashley; Azzawi, Soraya; Lopez, Alberto; Dang, Richard; Wang, Weisheng; Trieu, Brian; Tong, Joyce; Barrett, Ruth M.; Post, Rebecca J.; Baldi, Pierre; Abel, Ted; Lynch, Gary; Wood, Marcelo A. – Learning & Memory, 2017
Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it remains unclear how mutations in BAF complexes result in impaired cognitive function. Post-mitotic…
Descriptors: Intellectual Disability, Autism, Genetics, Neurological Impairments
Dynamic Expression of FKBP5 in the Medial Prefrontal Cortex Regulates Resiliency to Conditioned Fear
Criado-Marrero, Marangelie; Morales Silva, Roberto J.; Velazquez, Bethzaly; Hernández, Anixa; Colon, María; Cruz, Emmanuel; Soler-Cedeño, Omar; Porter, James T. – Learning & Memory, 2017
The factors influencing resiliency to the development of post-traumatic stress disorder (PTSD) remain to be elucidated. Clinical studies associate PTSD with polymorphisms of the FK506 binding protein 5 (FKBP5). However, it is unclear whether changes in FKBP5 expression alone could produce resiliency or susceptibility to PTSD-like symptoms. In this…
Descriptors: Brain, Conditioning, Fear, Posttraumatic Stress Disorder
Tamvacakis, Arianna N.; Senatore, Adriano; Katz, Paul S. – Learning & Memory, 2015
The sea slug "Hermissenda crassicornis" (Mollusca, Gastropoda, Nudibranchia) has been studied extensively in associative learning paradigms. However, lack of genetic information previously hindered molecular-level investigations. Here, the "Hermissenda" brain transcriptome was sequenced and assembled de novo, producing 165,743…
Descriptors: Animals, Genetics, Learning, Memory
Brian, Lisa A.; Lee, Bridgin G.; Lelay, John; Kaestner, Klaus H.; Blendy, Julie A. – Learning & Memory, 2015
The cAMP response element (CRE)-binding protein, CREB, is a transcription factor whose activity in the brain is critical for long-term memory formation. Phosphorylation of Ser133 in the kinase-inducible domain (KID), that in turn leads to the recruitment of the transcriptional coactivator CREB-binding protein (CBP), is thought to mediate the…
Descriptors: Brain, Biochemistry, Genetics, Learning
Bhattacharya, Sriya; Mukherjee, Bandhan; Doré, Jules J. E.; Yuan, Qi; Harley, Carolyn W.; McLean, John H. – Learning & Memory, 2017
Histone deacetylase (HDAC) plays a role in synaptic plasticity and long-term memory formation. We hypothesized that trichostatin-A (TSA), an HDAC inhibitor, would promote long-term odor preference memory and maintain enhanced GluA1 receptor levels that have been hypothesized to support memory. We used an early odor preference learning model in…
Descriptors: Long Term Memory, Inhibition, Olfactory Perception, Preferences
Sachser, Ricardo Marcelo; Crestani, Ana Paula; Quillfeldt, Jorge Alberto; e Souza, Tadeu Mello; de Oliveira Alvares, Lucas – Learning & Memory, 2015
Despite the fact that the cannabinoid receptor type 1 (CB1R) plays a pivotal role in emotional memory processing in different regions of the brain, its function in the retrosplenial cortex (RSC) remains unknown. Here, using contextual fear conditioning in rats, we showed that a post-training intra-RSC infusion of the CB1R antagonist AM251…
Descriptors: Genetics, Cognitive Processes, Brain, Memory
American Psychologist, 2012
Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…
Descriptors: Recognition (Achievement), Genetics, Brain, Profiles
Lapidus, Kyle A. B.; Nwokafor, Chiso; Scott, Daniel; Baroni, Timothy E.; Tenenbaum, Scott A.; Hiroi, Noboru; Singer, Robert H.; Czaplinski, Kevin – Learning & Memory, 2012
To directly address whether regulating mRNA localization can influence animal behavior, we created transgenic mice that conditionally express Zipcode Binding Protein 1 (ZBP1) in a subset of neurons in the brain. ZBP1 is an RNA-binding protein that regulates the localization, as well as translation and stability of target mRNAs in the cytoplasm. We…
Descriptors: Animals, Cocaine, Conditioning, Animal Behavior
