The purpose of the current study was to conduct a thorough review of the literature on the interview-informed synthesized contingency analysis (IISCA) developed by (Hanley et al., Journal of Applied Behavior Analysis 47:16-36, 2014)) and its subsequent treatment outcomes. A total of 39 articles were identified with 235 participants participating in 293 synthesized contingency analyses (SCAs) and 111 treatment evaluations. Results indicated that 95.56% of identified SCAs were reported to be differentiated. Similarly, reductions in problem behavior were seen in all 111 treatment analyses. Results of the current review, including effect size measures (i.e., Tau-U and Hedge's g), indicate that the IISCA and function-based interventions developed from the results of IISCA produce statistically significant results. Limitations and future directions are also discussed.