The university environment in the Nigerian context has a lot of stressors and such have the potential of impeding the work effectiveness of university staff. In the ideal situation, lecturers' target is to discharge their duties diligently, devoid of any limiting factor. However, when the environment is not conducive to achieving such a target, the expected result will be hampered. Studies on the management of stressful conditions abound, but none has targeted the Science and Agricultural education lecturers. This situation makes the researchers wonder how Science and Agricultural education lecturers manage their work stress. Thus, this research explored the effect of rational emotive behaviour therapy (REBT) on stress management among Science and Agricultural lecturers using a randomised controlled trial group experimental design. A sample of 186 participants randomly sampled from federal universities in Southeast Nigeria was involved in this research. An adopted perceived stress scale ([alpha] = 0.87) was used to get the necessary data for the study. The randomised evaluation lasted for 12 weeks, while data collected were analysed using Quade's analysis of covariance test. It was found that Science and Agricultural education lecturers who were exposed to 12-week REBT intervention had significantly lesser stress score than their counterparts who served as the waitlisted control group. In other words, it was concluded that Science and Agricultural education lecturers can effectively manage their stress through REBT intervention. Interestingly, the finding showed that the REBT group participants were able to retain their decreased job stress after a 3-month follow-up measure. Thus, one of the work ethics implications of these findings is that REBT's ability to reduce job stress can lead to improved work outputs. Hence, it is recommended that appropriate arrangements should be made by the university administration in southeast Nigeria to ensure that REBT intervention is implemented for the teaching staff of the university.